Egorova Ksenia S, Toukach Philip V
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, Moscow, Russia.
Glycobiology. 2017 Apr;27(4):285-290. doi: 10.1093/glycob/cww137. Epub 2016 Dec 23.
Glycosyltransferases (GTs) are carbohydrate-active enzymes (CAZy) involved in the synthesis of natural glycan structures. The application of CAZy is highly demanded in biotechnology and pharmaceutics. However, it is being hindered by the lack of high-quality and comprehensive repositories of the research data accumulated so far. In this paper, we describe a new curated Carbohydrate Structure Glycosyltransferase Database (CSDB_GT). Currently, CSDB_GT provides ca. 780 activities exhibited by GTs, as well as several other CAZy, found in Arabidopsis thaliana and described in ca. 180 publications. It covers most published data on A. thaliana GTs with evidenced functions. CSDB_GT is linked to the Carbohydrate Structure Database (CSDB), which stores data on archaeal, bacterial, fungal and plant glycans. The CSDB_GT data are supported by experimental evidences and can be traced to original publications. CSDB_GT is freely available at http://csdb.glycoscience.ru/gt.html.
糖基转移酶（GTs）是参与天然聚糖结构合成的碳水化合物活性酶（CAZy）。CAZy在生物技术和制药领域有很高的应用需求。然而，目前积累的研究数据缺乏高质量和全面的存储库，这阻碍了其应用。在本文中，我们描述了一个新的经过整理的碳水化合物结构糖基转移酶数据库（CSDB_GT）。目前，CSDB_GT提供了拟南芥中发现的约780种由GTs以及其他几种CAZy所表现出的活性，这些活性在约180篇出版物中有所描述。它涵盖了关于拟南芥GTs具有已证实功能的大多数已发表数据。CSDB_GT与碳水化合物结构数据库（CSDB）相链接，CSDB存储有关古细菌、细菌、真菌和植物聚糖的数据。CSDB_GT的数据有实验证据支持，并且可以追溯到原始出版物。CSDB_GT可在http://csdb.glycoscience.ru/gt.html免费获取。
