Ganaie Hilal A, Ali Md Niamat, Ganai Bashir A, Meraj Maryum, Ahmad Mudasar
Cytogenetics & Molecular Biology Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, 190 006, J & K, India; Phytochemistry Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, 190 006, J & K, India.
Cytogenetics & Molecular Biology Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, 190 006, J & K, India.
Microb Pathog. 2017 Feb;103:114-118. doi: 10.1016/j.micpath.2016.12.017. Epub 2016 Dec 21.
Ajuga bracteosa Wall ex. Benth. (Lamiaceae) commonly known as Bungle Weed has been in use since ancient times and is mentioned Ayurvedic literature. The upper ground parts of the plant are used for treatment of various diseases. The weed is credited with astringent, febrifugal, stimulant, aperient, tonic, diuretic and depurative properties and is used for the treatment of gout and rheumatism, palsy and amenorrhoea. Two compounds 1) 14, 15-dihydroajugapitin and 2) 8-o-acetylharpagide were isolated from the aerial parts of the plant and tested for antibacterial activity against various pathogenic bacteria by agar well diffusion method. Compound 1 and 2 showed maximum antibacterial activity against Escherichia coli with zone of inhibitions of 25. 0 ± 1.4 mm and 22.6 ± 0.9 mm respectively. The MIC value of compound 1 and 2 ranged between 500 and 1000 μg/ml. It could be concluded that both compounds isolated from the aerial parts of Ajuga bracteosa possess antibacterial activity against pathogens.
苞叶筋骨草（Ajuga bracteosa Wall ex. Benth.，唇形科），俗称“邦格尔草”，自古以来就被使用，阿育吠陀文献中也有提及。该植物的地上部分用于治疗各种疾病。这种杂草具有收敛、退热、刺激、通便、滋补、利尿和净化特性，用于治疗痛风、风湿、麻痹和闭经。从该植物地上部分分离出两种化合物：1）14,15 - 二氢筋骨草素和2）8 - O - 乙酰哈帕苷，并通过琼脂孔扩散法测试它们对各种病原菌的抗菌活性。化合物1和2对大肠杆菌显示出最大抗菌活性，抑菌圈分别为25.0±1.4毫米和22.6±0.9毫米。化合物1和2的最低抑菌浓度值在500至1000微克/毫升之间。可以得出结论，从苞叶筋骨草地上部分分离出的这两种化合物对病原菌均具有抗菌活性。
