自由基（FR）参与缺血性结肠炎的证据。

Evidence of free radical (FR) involvement in ischemic colitis.

作者信息

Douglas D M, Russell J C, Goren D, Dempsey S, Das D K

机构信息

Department of Surgery, University of Connecticut School of Medicine, Farmington 06032.

出版信息

Agents Actions. 1989 Jun;27(3-4):435-7. doi: 10.1007/BF01972844.

DOI:10.1007/BF01972844

PMID:2801335

Abstract

Early ischemic colitis was induced in rats to evaluate the roles of FRs and intraluminal content. After 30 minutes of ischemia, biopsies for histology, conjugated dienes (CD) and malonaldehyde (M), presumptive marker of lipid peroxidation, were obtained at 0, 30, and 60 minutes reperfusion. Histology was unchanged. CD and M were elevated in ischemic and saline controls, and rose progressively during reperfusion; CD and M were essentially the same as non-ischemic controls during reperfusion with intraluminal corticosteroid (c) and Alcide (A). These agents may be beneficial in early ischemic colitis.

摘要

在大鼠中诱导早期缺血性结肠炎，以评估自由基（FRs）和肠腔内物质的作用。缺血30分钟后，在再灌注0、30和60分钟时获取用于组织学、共轭二烯（CD）和丙二醛（M，脂质过氧化的推定标志物）检测的活检样本。组织学无变化。缺血组和生理盐水对照组的CD和M升高，且在再灌注期间逐渐上升；在肠腔内给予皮质类固醇（c）和阿尔西德（A）进行再灌注时，CD和M在再灌注期间与非缺血对照组基本相同。这些药物可能对早期缺血性结肠炎有益。