Khajeh Elias, Panahi Nekoo, Golpaie Atefeh, Shirvani Sepideh Hosseini, Afarideh Mohsen, Ghamarnejad Omid, Talebpour Mohammad, Hosseinzadeh-Attar Mohammad Javad
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Obes Surg. 2017 Jun;27(6):1596-1603. doi: 10.1007/s11695-016-2509-1.
We sought to investigate the short-term effect of weight loss following restrictive bariatric surgery on plasma concentrations of apelin and asymmetric dimethylarginine (ADMA) in individuals with morbid obesity.
SUBJECTS/METHODS: Thirty-seven morbidly obese individuals underwent laparoscopic greater curvature plication (LGCP). Anthropometric indices and plasma concentrations high-sensitivity C-reactive protein (hsCRP), apelin, and ADMA were measured before and 6 weeks after LGCP.
The percentage of total weight loss was 12.9 ± 4.4% 6 weeks after the operation. ADMA and apelin levels decreased significantly (p < 0.001 and 0.032, respectively) following LGCP. Significant decrements occurred in weight, body mass index, waist and hip circumference (p < 0.001), and waist-to-hip ratio (p = 0.013). The levels of triglycerides (p = 0.017), low-density lipoprotein cholesterol (p = 0.020), fasting plasma glucose (p = 0.033), fasting plasma insulin (p = 0.042), and the homeostasis model assessment index of insulin resistance (p = 0.034) also significantly decreased compared to the baseline measures. No significant change was observed in hsCRP levels and systolic and diastolic blood pressures. There was no significant correlation between changes in levels of apelin or ADMA and changes in anthropometric indices and other laboratory parameters.
Surgically induced weight loss rapidly decreases plasma levels of ADMA and apelin in morbidly obese patients. These changes do not seem correlated with changes in anthropometric and laboratory parameters associated with obesity.
我们试图研究限制性减肥手术后体重减轻对病态肥胖个体血浆中apelin和不对称二甲基精氨酸（ADMA）浓度的短期影响。
受试者/方法：37名病态肥胖个体接受了腹腔镜大弯折叠术（LGCP）。在LGCP术前及术后6周测量人体测量指标以及血浆中高敏C反应蛋白（hsCRP）、apelin和ADMA的浓度。
术后6周总体体重减轻百分比为12.9±4.4%。LGCP术后ADMA和apelin水平显著下降（分别为p<0.001和0.032）。体重、体重指数、腰围和臀围显著下降（p<0.001），腰臀比下降（p=0.013）。与基线测量值相比，甘油三酯（p=0.017）、低密度脂蛋白胆固醇（p=0.020）、空腹血糖（p=0.033）、空腹血浆胰岛素（p=0.042）以及胰岛素抵抗稳态模型评估指数（p=0.034）水平也显著降低。hsCRP水平以及收缩压和舒张压未观察到显著变化。apelin或ADMA水平的变化与人体测量指标和其他实验室参数的变化之间无显著相关性。
手术诱导的体重减轻迅速降低了病态肥胖患者血浆中ADMA和apelin的水平。这些变化似乎与肥胖相关的人体测量和实验室参数的变化无关。
