Ekman E T, Wallin G, Bäckdahl M, Löwhagen T, Auer G
Department of General Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Am J Clin Oncol. 1989 Oct;12(5):442-6. doi: 10.1097/00000421-198910000-00017.
The nuclear DNA content was measured in 36 cases of anaplastic giant-cell thyroid carcinoma registered at Radiumhemmet, Karolinska Hospital, Sweden, between November 1973 and December 1985. The DNA content was measured in morphologically identified single tumor cells by image cytometry. Either fine needle aspirate material or histologic sections from primary tumors, recurrences, or metastases were studied. All tumors were aneuploid. Aneuploidy decreased in four of seven tumors studied sequentially. Analysis of the nuclear DNA content did not provide additional prognostic information and did not explain why occasional patients enjoy longer survival than expected.
1973年11月至1985年12月期间，对瑞典卡罗林斯卡医院镭疗科登记的36例间变性巨细胞甲状腺癌进行了核DNA含量测定。通过图像细胞术在形态学上鉴定的单个肿瘤细胞中测量DNA含量。研究了来自原发性肿瘤、复发病灶或转移灶的细针穿刺抽吸材料或组织切片。所有肿瘤均为非整倍体。在依次研究的7个肿瘤中，有4个肿瘤的非整倍性降低。核DNA含量分析未提供额外的预后信息，也无法解释为何偶尔有患者的生存期比预期更长。
