Mackie Susan E, McHugh R Kathryn, McDermott Katherine, Griffin Margaret L, Winkelman John W, Weiss Roger D
Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02215; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115; Massachusetts General Hospital, 1 Bowdoin Square, 9th floor, Boston, MA 02114.
Harvard Medical School, 25 Shattuck Street, Boston, MA 02115; McLean Hospital, 115 Mill St., Belmont, MA 02478.
J Subst Abuse Treat. 2017 Feb;73:35-39. doi: 10.1016/j.jsat.2016.10.001. Epub 2016 Oct 6.
Restless legs syndrome (RLS) is a movement disorder associated with adverse health outcomes and decreased quality of life. Small case series suggest that symptoms of RLS occur during opioid withdrawal. However, the prevalence is unknown.
We conducted an observational study to determine the prevalence of RLS among inpatients patients receiving buprenorphine detoxification from opioids. To assess the specificity of RLS to opioid detoxification, we also evaluated patients receiving detoxification from alcohol as a comparison group. The diagnosis of RLS was established using a validated questionnaire.
The sample consisted of 124 adults with primary opioid use disorder and 180 with primary alcohol use disorder. In the total sample, 33.6% met a likely RLS diagnosis: 50.8% of those with opioid use disorder and 21.7% of those with alcohol use disorder (χ = 27.96[1,304] p < .001). In the logistic regression analysis controlling for socio-demographic and clinical variables, diagnosis of opioid use disorder was associated with more than twice the likelihood of RLS diagnosis (OR=2.05, 95% CI 1.09-3.88) relative to diagnosis of alcohol use disorder.
Approximately half of patients undergoing inpatient opioid detoxification exhibited the symptoms characteristic of RLS. We believe that these data support the existence of a secondary form of RLS associated with opioid withdrawal.
不宁腿综合征（RLS）是一种与不良健康后果及生活质量下降相关的运动障碍。小型病例系列研究表明，RLS症状在阿片类药物戒断期间出现。然而，其患病率尚不清楚。
我们进行了一项观察性研究，以确定接受阿片类药物丁丙诺啡脱毒治疗的住院患者中RLS的患病率。为评估RLS对阿片类药物脱毒的特异性，我们还评估了接受酒精脱毒治疗的患者作为对照组。使用经过验证的问卷对RLS进行诊断。
样本包括124名患有原发性阿片类药物使用障碍的成年人和180名患有原发性酒精使用障碍的成年人。在整个样本中，33.6%符合可能的RLS诊断：阿片类药物使用障碍患者中为50.8%，酒精使用障碍患者中为21.7%（χ = 27.96[1,304]，p <.001）。在控制社会人口统计学和临床变量的逻辑回归分析中，与酒精使用障碍诊断相比，阿片类药物使用障碍诊断与RLS诊断可能性高出两倍多相关（OR = 2.05，95%CI 1.09 - 3.88）。
接受住院阿片类药物脱毒治疗的患者中约有一半表现出RLS的特征性症状。我们认为这些数据支持存在一种与阿片类药物戒断相关的继发性RLS形式。
