NCRP for Cardiovascular and metabolic diseases, South African Medical research Council & University of Cape Town, Cape Town, South Africa.
Diabetol Metab Syndr. 2012 May 31;4(1):22. doi: 10.1186/1758-5996-4-22.
Available definition criteria for metabolic syndrome (MS) have similarities and inconsistencies. The aim of this study was to determine the prevalence of MS in a group of Cameroonians with type 2 diabetes, according to the International Diabetes Federation (IDF) and the National Cholesterol Education Programme Adult Treatment Panel III (NCEP-ATP III) criteria, and to assess the concordance between both criteria, and the implications of combining them.
We collected clinical and biochemical data for 308 patients with type 2 diabetes (men 157) at the National Obesity Center of the Yaounde Central Hospital, Cameroon. Concordance was assessed with the use of the Kappa statistic.
Mean age (standard deviation) was 55.8 (10.5) years and the median duration of diagnosed diabetes (25th-75th percentiles) was 3 years (0.5-5.0), similarly among men and women. The prevalence of MS was 71.7% according to the IDF criteria and 60.4% according to NCEP-ATP III criteria. The prevalence was significantly higher in women than in men independently of the criteria used (both p < 0.001). Overall concordance between both definitions was low to average 0.51 (95% confidence interval: 0.41-0.61). Combining the two sets of criteria marginally improved the yield beyond that provided by the IDF criteria alone in men, but not in the overall population and in women.
The IDF and NCEP-ATP III criteria do not always diagnose the same group of diabetic individuals with MS and combining them merely increases the yield beyond that provided by the IDF definition alone. This study highlights the importance of having a single unifying definition for MS in our setting.
代谢综合征（MS）的现有定义标准既有相似之处，也存在不一致。本研究的目的是根据国际糖尿病联合会（IDF）和美国国家胆固醇教育计划成人治疗专家组第三版（NCEP-ATP III）标准，确定一组喀麦隆 2 型糖尿病患者中 MS 的患病率，并评估两种标准之间的一致性，以及联合使用这些标准的影响。
我们收集了喀麦隆雅温得中央医院国家肥胖中心 308 名 2 型糖尿病患者（男性 157 名）的临床和生化数据。使用 Kappa 统计评估一致性。
平均年龄（标准差）为 55.8（10.5）岁，诊断为糖尿病的中位时间（25 至 75 百分位数）为 3 年（0.5 至 5.0），男性和女性相似。根据 IDF 标准，MS 的患病率为 71.7%，根据 NCEP-ATP III 标准，MS 的患病率为 60.4%。无论使用哪种标准，女性的患病率均明显高于男性（均 p<0.001）。两种定义之间的总体一致性低到中等，为 0.51（95%置信区间：0.41-0.61）。将两套标准结合起来，仅在男性中略微提高了比单独使用 IDF 标准更高的检出率，但在总体人群和女性中则不然。
IDF 和 NCEP-ATP III 标准并不总是诊断出相同的一组患有 MS 的糖尿病患者，将它们结合起来只会提高比单独使用 IDF 标准更高的检出率。本研究强调了在我们的环境中使用单一统一的 MS 定义的重要性。
