Wickens Jennifer M, Alsaab Hashem O, Kesharwani Prashant, Bhise Ketki, Amin Mohd Cairul Iqbal Mohd, Tekade Rakesh Kumar, Gupta Umesh, Iyer Arun K
Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA; Department of Chemistry, Lake Superior State University, 680 W. Easterday Avenue, Sault Ste. Marie, MI 49783, USA.
Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA.
Drug Discov Today. 2017 Apr;22(4):665-680. doi: 10.1016/j.drudis.2016.12.009. Epub 2016 Dec 23.
The cluster-determinant 44 (CD44) receptor has a high affinity for hyaluronic acid (HA) binding and is a desirable receptor for active targeting based on its overexpression in cancer cells compared with normal body cells. The nanocarrier affinity can be increased by conjugating drug-loaded carriers with HA, allowing enhanced cancer cell uptake via the HA-CD44 receptor-mediated endocytosis pathway. In this review, we discuss recent advances in HA-based nanocarriers and micelles for cancer therapy. In vitro and in vivo experiments have repeatedly indicated HA-based nanocarriers to be a target-specific drug and gene delivery platform with great promise for future applications in clinical cancer therapy.
簇决定簇44(CD44)受体对透明质酸(HA)具有高亲和力,并且由于其在癌细胞中相对于正常体细胞的过表达,是基于主动靶向的理想受体。通过将载药载体与HA缀合,可以提高纳米载体的亲和力,从而通过HA-CD44受体介导的内吞途径增强癌细胞摄取。在本综述中,我们讨论了用于癌症治疗的基于HA的纳米载体和胶束的最新进展。体外和体内实验反复表明,基于HA的纳米载体是一种靶向特异性药物和基因递送平台,在临床癌症治疗的未来应用中具有巨大潜力。