Aziz Nafe, Pandey Rishikesh, Barman Ishan, Prasad Ram
Amity Institute of Microbial Technology, Amity University, Noida India.
Connecticut Children's Innovation Center, FarmingtonCT, USA; Department of Pediatrics, University of Connecticut Health, FarmingtonCT, USA.
Front Microbiol. 2016 Dec 15;7:1984. doi: 10.3389/fmicb.2016.01984. eCollection 2016.
Driven by the need to engineer robust surface coatings for medical devices to prevent infection and sepsis, incorporation of nanoparticles has surfaced as a promising avenue to enhance non-fouling efficacy. Microbial synthesis of such nanoscale metallic structures is of substantive interest as this can offer an eco-friendly, cost-effective, and sustainable route for further development. Here we present a -derived fungal route for synthesis of silver nanoparticles, which display significant antimicrobial properties when tested against six pathological bacterial strains (, and ) and three pathological fungal strains (, and ). These antimicrobial attributes were comparable to those of established antibiotics (streptomycin, tetracycline, kanamycin, and rifampicin) and fungicides (amphotericin B, fluconazole, and ketoconazole), respectively. Importantly, these nanoparticles show significant synergistic characteristics when combined with the antibiotics and fungicides to offer substantially greater resistance to microbial growth. The blend of antibacterial and antifungal properties, coupled with their intrinsic "green" and facile synthesis, makes these biogenic nanoparticles particularly attractive for future applications in nanomedicine ranging from topical ointments and bandages for wound healing to coated stents.
出于为医疗设备设计坚固表面涂层以预防感染和败血症的需求，纳米颗粒的掺入已成为增强防污功效的一条有前景的途径。微生物合成此类纳米级金属结构具有重大意义，因为这可为进一步开发提供一条环保、经济高效且可持续的途径。在此，我们展示了一种源自真菌的合成银纳米颗粒的途径，当针对六种致病性细菌菌株（[具体细菌菌株名称未给出]）和三种致病性真菌菌株（[具体真菌菌株名称未给出]）进行测试时，这些银纳米颗粒表现出显著的抗菌特性。这些抗菌特性分别与已有的抗生素（链霉素、四环素、卡那霉素和利福平）和杀菌剂（两性霉素B、氟康唑和酮康唑）相当。重要的是，当这些纳米颗粒与抗生素和杀菌剂联合使用时，它们表现出显著的协同特性，对微生物生长具有更强的抗性。抗菌和抗真菌特性的结合，以及其固有的“绿色”且简便的合成方法，使得这些生物合成的纳米颗粒在未来纳米医学应用中极具吸引力，这些应用范围从用于伤口愈合的局部药膏和绷带到涂层支架。
