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人输卵管液中的精子抗体活性。

Sperm antibody activity in human fallopian tube fluid.

作者信息

Ping W W

出版信息

Fertil Steril. 1979 Dec;32(6):681-4. doi: 10.1016/s0015-0282(16)44419-5.

DOI:10.1016/s0015-0282(16)44419-5
PMID:574463
Abstract

Fallopian tube fluid and sera from 33 fertile and 48 infertile patients were investigated for spermatozoal antibodies by gelatin agglutination, immobilization, and indirect immunofluorescence tests. Oviductal fluids were obtained as washings after tubal catheterization. The incidences of antisperm activity in oviductal washings ranged from 9% to 58.3% depending on the tests used. These incidences were higher in infertile patients. Only immunoglobulin (Ig) A antisperm antibody was significantly more common in infertile patients than in fertile patients (P less than 0.01). Gelatin agglutination and antisperm IgG activity in the oviductal washings could be correlated to that in the sera. No relationship was seen between antisperm activity in the oviductal washings and that in the sera for sperm immobilization antibodies and IgA antisperm antibodies.

摘要

通过明胶凝集试验、制动试验和间接免疫荧光试验,对33名有生育能力的患者和48名不孕患者的输卵管液及血清进行了精子抗体检测。输卵管液是在输卵管插管术后作为冲洗液获取的。根据所采用的检测方法,输卵管冲洗液中抗精子活性的发生率在9%至58.3%之间。不孕患者中的这些发生率更高。仅免疫球蛋白(Ig)A抗精子抗体在不孕患者中比在有生育能力的患者中显著更常见(P小于0.01)。输卵管冲洗液中的明胶凝集和抗精子IgG活性与血清中的相关。在输卵管冲洗液中的抗精子制动抗体和IgA抗精子抗体活性与血清中的活性之间未发现关联。

相似文献

1
Sperm antibody activity in human fallopian tube fluid.人输卵管液中的精子抗体活性。
Fertil Steril. 1979 Dec;32(6):681-4. doi: 10.1016/s0015-0282(16)44419-5.
2
Local production of antisperm antibodies in infertile women.不孕女性体内抗精子抗体的局部产生。
Med J Aust. 1979 Nov 17;2(10):511-4. doi: 10.5694/j.1326-5377.1979.tb127140.x.
3
The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility.不育夫妇中抗精子抗体对精子 - 宫颈黏液相互作用及后续生育能力的发生率和影响。
Fertil Steril. 1982 Oct;38(4):439-46. doi: 10.1016/s0015-0282(16)46578-7.
4
Flow cytometry study on the effect of serum and peritoneal fluid of women on sperm-binding activity of immunoglobulin G antisperm antibodies.关于女性血清和腹腔液对免疫球蛋白G抗精子抗体精子结合活性影响的流式细胞术研究
Fertil Steril. 1997 Apr;67(4):680-6. doi: 10.1016/s0015-0282(97)81366-0.
5
The clinical relevance of classes of immunoglobulins on spermatozoa from infertile and vasovasostomized males.不育男性和输精管吻合术后男性精子上免疫球蛋白类别的临床相关性。
Fertil Steril. 1985 Apr;43(4):621-7. doi: 10.1016/s0015-0282(16)48507-9.
6
Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies.可中和抗精子抗体的可育女性血清中精子的抗独特型抗体。
J Clin Invest. 1993 Nov;92(5):2331-8. doi: 10.1172/JCI116837.
7
Low fertility rate in vasovasostomized males and its possible immunologic mechanism.输精管吻合术后男性的低生育率及其可能的免疫机制。
Int J Fertil. 1975;20(3):183-91.
8
Immunoglobulin (Ig) G, IgA, and IgA subclass antibodies against fertilization antigen-1 in cervical secretions and sera of women of infertile couples.不孕夫妇女性宫颈分泌物和血清中针对受精抗原-1的免疫球蛋白(Ig)G、IgA及IgA亚类抗体。
Fertil Steril. 1993 Oct;60(4):658-63. doi: 10.1016/s0015-0282(16)56217-7.
9
Relationship between circulating antisperm antibodies in women and autoantibodies on the ejaculated sperm of their partners.女性循环抗精子抗体与其伴侣射出精子上自身抗体之间的关系。
Am J Obstet Gynecol. 1989 Oct;161(4):900-3. doi: 10.1016/0002-9378(89)90747-3.
10
A comparison of sperm agglutination and immobilization assays with a quantitative ELISA for anti-sperm antibody in serum.血清中抗精子抗体定量酶联免疫吸附测定法与精子凝集和制动试验的比较。
Fertil Steril. 1986 Aug;46(2):285-92. doi: 10.1016/s0015-0282(16)49527-0.

引用本文的文献

1
Sperm artificially exposed to antisperm antibodies show altered deoxyribonucleic acid.人工暴露于抗精子抗体的精子显示出脱氧核糖核酸的改变。
J Assist Reprod Genet. 1999 Sep;16(8):443-9. doi: 10.1023/a:1020525726674.