Youn Dou Yeon, Xiaoli Alus M, Pessin Jeffrey E, Yang Fajun
Division of Endocrinology, Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461 USA ; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461 USA.
Division of Endocrinology, Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461 USA ; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461 USA.
Biophys Rep. 2016;2(2):69-77. doi: 10.1007/s41048-016-0031-6. Epub 2016 Nov 1.
The Mediator complex was originally discovered in yeast, but it is conserved in all eukaryotes. Its best-known function is to regulate RNA polymerase II-dependent gene transcription. Although the mechanisms by which the Mediator complex regulates transcription are often complicated by the context-dependent regulation, this transcription cofactor complex plays a pivotal role in numerous biological pathways. Biochemical, molecular, and physiological studies using cancer cell lines or model organisms have established the current paradigm of the Mediator functions. However, the physiological roles of the mammalian Mediator complex remain poorly defined, but have attracted a great interest in recent years. In this short review, we will summarize some of the reported functions of selective Mediator subunits in the regulation of metabolism. These intriguing findings suggest that the Mediator complex may be an important player in nutrient sensing and energy balance in mammals.
中介体复合物最初是在酵母中发现的，但在所有真核生物中都保守存在。其最广为人知的功能是调节RNA聚合酶II依赖性基因转录。尽管中介体复合物调节转录的机制常常因依赖于上下文的调节而变得复杂，但这个转录辅助因子复合物在众多生物途径中都起着关键作用。使用癌细胞系或模式生物进行的生化、分子和生理学研究已经确立了中介体功能的当前范式。然而，哺乳动物中介体复合物的生理作用仍不清楚，但近年来已引起了极大的关注。在这篇简短的综述中，我们将总结一些已报道的选择性中介体亚基在代谢调节中的功能。这些有趣的发现表明，中介体复合物可能是哺乳动物营养感知和能量平衡中的一个重要参与者。
