Sagawa Eri, Okubo Hironao, Sorin Yushi, Nakadera Eisuke, Fukada Hiroo, Igusa Yuki, Kokubu Shigehiro, Miyazaki Akihisa, Watanobe Ikuo, Sugo Hiroyuki, Kojima Kuniaki, Watanabe Sumio
Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
Institute for liver disease minimal invasive treatment, Shin-Yurigaoka General Hospital, Tokyo, Japan.
Hepatol Res. 2017 Nov;47(12):1235-1240. doi: 10.1111/hepr.12858. Epub 2017 Feb 6.
The indocyanine green (ICG) finger-piece method (FPM), which allows measurement of the ICG concentration by mounting a light sensor onto a finger, is used to assess liver function. We compared the ICG FPM with the conventional ICG blood sampling method (BSM) in patients with liver disorders.
Ninety consecutive patients simultaneously underwent the ICG BSM and ICG FPM. After ICG administration, blood samples were collected at 5, 10, and 15 min for the ICG BSM. The ICG concentration was measured through the finger piece by an ICG clearance meter.
Seventy-one patients (78.9%) had Child-Pugh class A liver disease, and 19 (21.1%) had class B or C. The FPM-measured ICG plasma disappearance rate was positively correlated with the BSM-measured values (r = 0.886, P < 0.001). Bland-Altman analysis showed good agreement between the two methods (mean difference, 0.012 ± 0.018). The FPM-measured ICG plasma disappearance rate was positively correlated with the BSM-measured values both in patients with Child-Pugh class A liver disease (r = 0.821, P < 0.001) and class B or C liver disease (r = 0.859, P < 0.001).
The ICG FPM may be an alternative to the ICG BSM for liver function assessment.
吲哚菁绿（ICG）指套法（FPM）通过将光传感器安装在手指上测量ICG浓度，用于评估肝功能。我们比较了ICG FPM与传统ICG血样采集法（BSM）在肝病患者中的应用。
连续90例患者同时接受ICG BSM和ICG FPM检测。注射ICG后，在5、10和15分钟采集血样用于ICG BSM检测。通过ICG清除仪经指套测量ICG浓度。
71例患者（78.9%）为Child-Pugh A级肝病，19例（21.1%）为B级或C级。FPM测量的ICG血浆消失率与BSM测量值呈正相关（r = 0.886，P < 0.001）。Bland-Altman分析显示两种方法一致性良好（平均差异，0.012 ± 0.018）。在Child-Pugh A级肝病患者（r = 0.821，P < 0.001）和B级或C级肝病患者（r = 0.859，P < 0.001）中，FPM测量的ICG血浆消失率均与BSM测量值呈正相关。
ICG FPM可作为ICG BSM评估肝功能的替代方法。
