Karseeva Elina, Kolokolnikov Ilya, Medvedeva Ekaterina, Savchenko Elena
Higher School of Applied Physics and Space Technologies, Institute of Electronics and Telecommunications, Peter the Great St. Petersburg Polytechnic University, Saint Petersburg 195251, Russia.
Computer Information Systems Department, International University of Kyrgyzstan, Bishkek 720010, Kyrgyzstan.
Diagnostics (Basel). 2023 Mar 28;13(7):1269. doi: 10.3390/diagnostics13071269.
A pressing health problem, both in clinical and socio-economic terms, is the increase in the number of patients with liver damage caused by viral diseases (hepatitis), cancer, toxicological damage, or metabolic disorders. Liver function assessment is a complex task, for which various existing diagnostic methods are used. Unfortunately, they all have several limitations which frequently make prompt and accurate diagnosis impossible. The high level of disability and mortality caused by liver diseases makes the development of new liver diagnostic methods very urgent. In this paper, we describe a new joint methodology for studying liver function based on optical densitometry and dynamic light scattering. This will help to diagnose and predict the dynamics of liver function during treatment with greater efficiency, due to including in consideration the individual characteristics of the cardiovascular system and tissue metabolism. In this paper, we present a laboratory model of a combined sensor for optical densitometry and dynamic light scattering. We also developed special software for controlling the sensor and processing the recorded data. Modeling experiments and physical medical studies were carried out to adjust and calibrate the sensor and software. We also assessed the sensor resolution when registering the concentration of dye in the human body and the minimum measured flow rate.
从临床和社会经济角度来看，一个紧迫的健康问题是由病毒性疾病（肝炎）、癌症、毒理学损伤或代谢紊乱导致的肝损伤患者数量不断增加。肝功能评估是一项复杂的任务，为此人们使用了各种现有的诊断方法。不幸的是，它们都有一些局限性，这常常使得快速准确的诊断无法实现。肝病导致的高致残率和死亡率使得开发新的肝脏诊断方法变得非常迫切。在本文中，我们描述了一种基于光密度测定法和动态光散射研究肝功能的新联合方法。由于考虑了心血管系统和组织代谢的个体特征，这将有助于更高效地诊断和预测治疗期间肝功能的动态变化。在本文中，我们展示了一种用于光密度测定和动态光散射的组合传感器的实验室模型。我们还开发了用于控制传感器和处理记录数据的专用软件。进行了建模实验和物理医学研究以调整和校准传感器及软件。我们还评估了传感器在记录人体染料浓度时的分辨率以及最小测量流速。
