Saito Hitomi, Cherasse Yoan, Suzuki Rina, Mitarai Makoto, Ueda Fumitaka, Urade Yoshihiro
Pharmaceutical and Healthcare Research Laboratories, FUJIFILM Corporation, Kanagawa, Japan.
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600882. Epub 2017 Feb 27.
Zinc is an essential mineral that plays an important role in the body. We previously reported that orally feeding zinc-enriched yeast to mice induces nonrapid-eye-movement sleep. In addition, astaxanthin, an antioxidant abundant in seafood such as salmon and krill, is able to chelate minerals and may promote zinc absorption, which in return may also improve sleep. The purpose of our study was to examine the effect of zinc-rich and astaxanthin-containing food on sleep in humans.
We conducted a randomized, double-blinded, placebo-controlled parallel group trial of 120 healthy subjects and recorded their night activity by actigraphy for 12 weeks. These subjects were divided into four groups: placebo, zinc-rich food, zinc-, and astaxanthin-rich food, and placebo supplemented with zinc-enriched yeast and astaxanthin oil. Compared with the placebo group, the zinc-rich food group efficiently decreased the time necessary to fall asleep and improved sleep efficiency, whereas the group that ingested zinc-enriched yeast and astaxanthin oil significantly improved the sleep onset latency.
Actigraphic sleep monitoring demonstrated that eating zinc-rich food improved sleep onset latency as well as improved the sleep efficiency in healthy individuals.
锌是一种必需矿物质，在人体中发挥着重要作用。我们之前报道过，给小鼠口服富含锌的酵母可诱导非快速眼动睡眠。此外，虾青素是一种在三文鱼和磷虾等海鲜中大量存在的抗氧化剂，它能够螯合矿物质并可能促进锌的吸收，而这反过来也可能改善睡眠。我们研究的目的是检验富含锌且含虾青素的食物对人类睡眠的影响。
我们对120名健康受试者进行了一项随机、双盲、安慰剂对照的平行组试验，并通过活动记录仪记录他们12周的夜间活动情况。这些受试者被分为四组：安慰剂组、富含锌的食物组、富含锌和虾青素的食物组，以及补充了富含锌的酵母和虾青素油的安慰剂组。与安慰剂组相比，富含锌的食物组有效缩短了入睡所需时间并提高了睡眠效率，而摄入富含锌的酵母和虾青素油的组显著改善了入睡潜伏期。
活动记录仪睡眠监测表明，食用富含锌的食物可改善健康个体的入睡潜伏期并提高睡眠效率。
