Yeom Ji Won, Cho Chul-Hyun
Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Psychiatry Investig. 2024 Aug;21(8):810-821. doi: 10.30773/pi.2024.0121. Epub 2024 Aug 2.
Herbal and natural supplements have gained popularity as alternative treatments to insomnia and sleep disorders due to their perceived safety and potential effectiveness. This literature review summarizes the current evidence on the efficacy, safety, and mechanisms of action of commonly used supplements for sleep, including valerian, hops, kava, German chamomile, cherry, tryptophan, theanine, melatonin, magnesium, and zinc.
We conducted literature review of clinical research on herbal and supplements for sleep reported to date. We summarized key findings and reviewed outcomes related to clinical efficacy and side effects.
Findings suggest that certain supplements, particularly valerian, hops, and melatonin, could be effective in improving sleep quality and reducing insomnia symptoms through modulation of neurotransmitter systems and regulation of sleep-wake cycles. However, the strength of the evidence varies with unestablished optimal dosages, formulations, and treatment durations. Although generally considered safe, these supplements are not without risks, such as rare but serious adverse effects associated with kava and potential interactions with prescription medications. The quality and purity of supplements also vary widely due to a lack of strict regulations.
Healthcare providers should remain informed about the latest research and work closely with patients to develop personalized treatment plans. Herbal and natural supplements may offer promising alternatives or adjunct treatments for insomnia and sleep disorders, but their use should be guided by the best available evidence and individual patient requirements. Larger, well-designed clinical trials are needed to establish the efficacy and safety of these supplements for clinical decision-making.
草药和天然补充剂因其被认为的安全性和潜在有效性,作为失眠和睡眠障碍的替代疗法而受到欢迎。这篇文献综述总结了目前关于常用睡眠补充剂(包括缬草、啤酒花、卡瓦、德国洋甘菊、樱桃、色氨酸、茶氨酸、褪黑素、镁和锌)的疗效、安全性及作用机制的证据。
我们对迄今报道的关于草药和睡眠补充剂的临床研究进行了文献综述。我们总结了主要发现,并回顾了与临床疗效和副作用相关的结果。
研究结果表明,某些补充剂,特别是缬草、啤酒花和褪黑素,可能通过调节神经递质系统和调节睡眠-觉醒周期来有效改善睡眠质量并减轻失眠症状。然而,证据的力度因未确定的最佳剂量、配方和治疗持续时间而有所不同。尽管通常被认为是安全的,但这些补充剂并非没有风险,例如与卡瓦相关的罕见但严重的不良反应以及与处方药的潜在相互作用。由于缺乏严格监管,补充剂的质量和纯度也存在很大差异。
医疗保健提供者应了解最新研究,并与患者密切合作制定个性化治疗方案。草药和天然补充剂可能为失眠和睡眠障碍提供有前景的替代或辅助治疗方法,但它们的使用应以现有最佳证据和个体患者需求为指导。需要进行更大规模、设计良好的临床试验来确定这些补充剂在临床决策中的疗效和安全性。