Jazinaki Mostafa Shahraki, Gheflati Alireza, Moghadam Mohammad Reza Shadmand Foumani, Hadi Saeid, Razavidarmian Maryam, Nezhad Masoud Yaghob, Akhtari Hale, Nematizadeh Mona, Safarian Mohammad
Department of Nutrition Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Department of Nutrition Sciences Varastegan Institute for Medical Sciences Mashhad Iran.
Health Sci Rep. 2024 Oct 6;7(10):e70019. doi: 10.1002/hsr2.70019. eCollection 2024 Oct.
Alternative therapies, such as zinc supplementation, have been explored as potential interventions for sleep disorders. However, the efficacy of zinc supplementation in improving sleep quality remains uncertain. This systematic review aims to examine the impacts of zinc supplementation on sleep quality in humans.
The Web of Science, Medline, Scopus, and Google Scholar databases were comprehensively searched to find studies investigating the effect of zinc supplementation on sleep quality. After identifying relevant studies by screening, relevant data were extracted from them. The quality assessment was conducted using the Cochrane quality assessment tool.
This systematic review included eight studies. The interventions ranged from 4 to 48 weeks, with a daily dose of zinc supplementation varying between 10 and 73.3 mg. The majority of the evidence examined in this review pointed to the significant improvement effect of zinc supplementation on sleep quality in adults compared to the control groups. Furthermore, zinc supplementation did not have a significant effect on sleep disorders. However, there was no consensus about these findings. Also, the effect of supplementation on sleep duration in nonadults was contradictory.
This systematic review suggests that zinc supplementation may lead to improvements in sleep quality. However, more research, primarily clinical trials, is needed to clarify the beneficial effects of zinc supplementation on sleep quality with consideration of dietary zinc intake and the Recommended Dietary Allowances of zinc (RDA) in the different populations. It is also recommended to investigate the effect of zinc supplementation on sleep quality in people with zinc deficiency in future studies.
诸如补充锌等替代疗法已被探索作为睡眠障碍的潜在干预措施。然而，补充锌对改善睡眠质量的疗效仍不确定。本系统评价旨在研究补充锌对人类睡眠质量的影响。
全面检索科学网、医学期刊数据库、Scopus数据库和谷歌学术数据库，以查找研究补充锌对睡眠质量影响的研究。通过筛选确定相关研究后，从中提取相关数据。使用Cochrane质量评估工具进行质量评估。
本系统评价纳入了八项研究。干预时间从4周到48周不等，每日补充锌的剂量在10至73.3毫克之间。本评价中审查的大多数证据表明，与对照组相比，补充锌对成年人的睡眠质量有显著改善作用。此外，补充锌对睡眠障碍没有显著影响。然而，对于这些发现尚无共识。而且，补充锌对非成年人睡眠时长的影响存在矛盾。
本系统评价表明，补充锌可能会改善睡眠质量。然而，需要更多研究，主要是临床试验，以在考虑不同人群的膳食锌摄入量和锌的推荐膳食摄入量（RDA）的情况下，阐明补充锌对睡眠质量的有益影响。还建议在未来研究中调查补充锌对锌缺乏人群睡眠质量的影响。
