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变应性支气管肺曲霉病在巴西确实存在。

Allergic bronchopulmonary aspergillosis does exist in Brazil.

作者信息

Geller M

机构信息

Geller Allergy/Immunology Clinic, Rio de Janeiro, Brazil.

出版信息

Ann Allergy. 1989 Oct;63(4):325-6.

PMID:2802269
Abstract

A case of allergic bronchopulmonary aspergillosis is presented. The patient had corticosteroid-dependent asthma, recurrent pulmonary infiltrates clearing with oral prednisone bursts, positive dual (immediate and late) skin test (prick and intradermal) reactivity to Aspergillus fumigatus, 11% blood eosinophilia, elevated total serum IgE, positive precipitating antibody against Aspergillus fumigatus, and elevated specific serum antibodies to Aspergillus fumigatus (positive IgE and IgG antibody indices, and elevated IgE levels by both RAST and FAST). To our knowledge this is the first immunologically documented case of allergic bronchopulmonary aspergillosis in Brazil. Future survey studies are required.

摘要

本文报告一例变应性支气管肺曲霉病病例。该患者患有依赖皮质类固醇的哮喘,口服泼尼松冲击治疗后反复出现的肺部浸润影消散,对烟曲霉的双重(即刻和迟发)皮肤试验(点刺和皮内)反应呈阳性,血嗜酸性粒细胞增多达11%,总血清IgE升高,抗烟曲霉沉淀抗体阳性,以及针对烟曲霉的特异性血清抗体升高(IgE和IgG抗体指数阳性,且通过放射性变应原吸附试验和荧光变应原吸附试验检测IgE水平均升高)。据我们所知,这是巴西首例有免疫学记录的变应性支气管肺曲霉病病例。需要开展进一步的调查研究。

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