Quast Kathleen B, Ung Kevin, Froudarakis Emmanouil, Huang Longwen, Herman Isabella, Addison Angela P, Ortiz-Guzman Joshua, Cordiner Keith, Saggau Peter, Tolias Andreas S, Arenkiel Benjamin R
Department of Molecular &Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.
Nat Neurosci. 2017 Feb;20(2):189-199. doi: 10.1038/nn.4467. Epub 2016 Dec 26.
Sensory maps are created by networks of neuronal responses that vary with their anatomical position, such that representations of the external world are systematically and topographically organized in the brain. Current understanding from studying excitatory maps is that maps are sculpted and refined throughout development and/or through sensory experience. Investigating the mouse olfactory bulb, where ongoing neurogenesis continually supplies new inhibitory granule cells into existing circuitry, we isolated the development of sensory maps formed by inhibitory networks. Using in vivo calcium imaging of odor responses, we compared functional responses of both maturing and established granule cells. We found that, in contrast to the refinement observed for excitatory maps, inhibitory sensory maps became broader with maturation. However, like excitatory maps, inhibitory sensory maps are sensitive to experience. These data describe the development of an inhibitory sensory map as a network, highlighting the differences from previously described excitatory maps.
感觉图谱是由神经元反应网络创建的，这些反应随其解剖位置而变化，从而使外部世界的表征在大脑中以系统的、拓扑的方式组织起来。目前对兴奋性图谱的研究表明，图谱在整个发育过程中和/或通过感觉经验被塑造和完善。在研究小鼠嗅球时，持续的神经发生不断地将新的抑制性颗粒细胞供应到现有的神经回路中，我们分离出了由抑制性网络形成的感觉图谱的发育过程。通过对气味反应进行体内钙成像，我们比较了成熟颗粒细胞和已成熟颗粒细胞的功能反应。我们发现，与兴奋性图谱中观察到的精细化相反，抑制性感觉图谱随着成熟而变得更宽。然而，与兴奋性图谱一样，抑制性感觉图谱对经验敏感。这些数据将抑制性感觉图谱的发育描述为一个网络，突出了与先前描述的兴奋性图谱的差异。
