[侵袭性与惰性B细胞非霍奇金淋巴瘤之间的肝炎病毒感染差异分析]

[Divergence Analysis of Hepatitis Virus Infection between Aggressive and Indolent B Cell Non-Hodgkin's Lymphoma].

作者信息

Xiong Wen-Jie, Li Heng, Liu Hui-Min, Yi Shu-Hua, Li Zeng-Jun, Lu Rui, Liu Wei, Zou De-Hui, Qiu Lu-Gui

机构信息

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Dec;24(6):1754-1758. doi: 10.7534/j.issn.1009-2137.2016.06.025.

DOI:10.7534/j.issn.1009-2137.2016.06.025

PMID:28024489

Abstract

OBJECTIVE

To investigate the prevalence rate of hepatitis B virus(HBV)and hepatitis C virus(HCV)between aggressive and indolent B cell non-Hodgkin's lymphoma (B-NHL), and to compare the different infection rate of Hepatifis Virus between the 2 groups.

METHODS

Integrated clinical information of 733 newly diagnosed indolent B-NHL patients and 148 aggressive B-NHL patients from January 1994 to January 2014 was retrospectively analyzed. The difference of hepatitis virus infection was compared between the 2 groups.

RESULTS

The positive rate of HCV-Ab was 1.8% in 881 newly diagnosed B-NHL patients. The HCV prevalence was 1.9% and 1.35% in the indolent and aggressive B-NHL group respecitvely. Compared with general population, the HCV positive rate was significantly higher in the whole B-NHL group and the indolent group(1.8% vs 0.4%,1.9% vs 1.4%)(P<0.01), while it was not significantly different in the aggressive group (1.35% vs 0.4%)(P=0.068). The positive rate of HCV-Ab was not significantly different between the indolent and the aggressive group (1.9% vs 1.35%)(P=0.639). The HBs-Ag positive rate in the whole B-NHL group was 9.0%, which was significantly higher than that in the general population (9.0% vs 7.2%)(P<0.05). The positive rate of HBs-Ag in the indolent and aggressive B-NHL group was 7.9% and 14.2%, respectively. It was significantly higher in the aggressive group than that in the indolent one (14.2% vs 7.2%)(P<0.01). Compared with the general population, the aggressive group had significantly higher prevalence rate of HBV. However, it was not significantly different between the indolent group and the general population (7.9% vs 7.2%)(P>0.05).In the aggressive B-NHL group,the co-expression of HBs-Ag,HBe-Ag and anti-HBc-Ab was 4.4%, which was higher than that in the indolent one (4.7% vs 1.2%)(P<0.01). However, compared with the indolent group, the co-expression of HBs-Ag, anti-HBe-Ab and anti-HBc-Ab was not significantly different in the aggressive group (5.5% vs 6.1%)(P>0.05).

CONCLUSION

The HCV is more relevant with indolent B-NHL, the HBV has more relevance with the aggressive patients.

摘要

目的

探讨侵袭性与惰性B细胞非霍奇金淋巴瘤（B-NHL）中乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的感染率，并比较两组之间肝炎病毒的不同感染率。

方法

回顾性分析1994年1月至2014年1月期间733例新诊断的惰性B-NHL患者和148例侵袭性B-NHL患者的临床资料。比较两组之间肝炎病毒感染的差异。

结果

881例新诊断的B-NHL患者中HCV-Ab阳性率为1.8%。惰性和侵袭性B-NHL组的HCV感染率分别为1.9%和1.35%。与普通人群相比，整个B-NHL组和惰性组的HCV阳性率显著更高（1.8%对0.4%，1.9%对1.4%）（P<0.01），而侵袭性组则无显著差异（1.35%对0.4%）（P=0.068）。惰性组和侵袭性组之间的HCV-Ab阳性率无显著差异（1.9%对1.35%）（P=0.639）。整个B-NHL组的HBs-Ag阳性率为9.0%，显著高于普通人群（9.0%对7.2%）（P<0.05）。惰性和侵袭性B-NHL组的HBs-Ag阳性率分别为7.9%和14.2%。侵袭性组显著高于惰性组（14.2%对7.2%）（P<0.01）。与普通人群相比，侵袭性组的HBV感染率显著更高。然而惰性组与普通人群之间无显著差异（7.9%对7.2%）（P>0.05）。在侵袭性B-NHL组中，HBs-Ag、HBe-Ag和抗-HBc-Ab的共表达率为4.4%，高于惰性组（4.7%对1.2%）（P<0.01）。然而，与惰性组相比，侵袭性组中HBs-Ag、抗-HBe-Ab和抗-HBc-Ab的共表达无显著差异（5.5%对6.1%）（P>0.05）。