Güleç Ayşegül, Bakkalbaşı Banu Çakırer, Cumbul Alev, Uslu Ünal, Alev Burçin, Yarat Ayşen
Department of Orthodontics, School of Dentistry, University of Marmara, Istanbul, Turkey.
Department of Orthodontics, School of Dentistry, University of Marmara, Istanbul, Turkey.
Am J Orthod Dentofacial Orthop. 2017 Jan;151(1):92-104. doi: 10.1016/j.ajodo.2016.05.016.
The aims of this study were to determine the effects of different concentrations of platelet-rich plasma (PRP) on alveolar bone density and orthodontic tooth movement.
Seventy-six rats were divided into 2 groups: a moderate concentration PRP injection group (n = 38) and a high concentration PRP injection group (n = 38). In each group, 5 time points were studied: 3, 7, 14, 21, and 60 days. Before orthodontic mesialization of the maxillary first molars, moderate and high concentrations of PRP were injected on the right sides of the molar buccal sulcus, and the left sides served as the controls. Tooth movements were measured on 3-dimensional digital models. Alveolar bone volume density and osteoclastic activity in the first molar intraradicular areas were evaluated by histomorphometric analysis.
Alveolar bone density was decreased in the experimental groups compared with the control groups (P = 0.0001) at 3, 7, 14, and 21 days. On day 3, osteoclastic activity of the experimental groups was higher than that of the controls (P = 0.044, P = 0.0001). On day 21, the amounts of tooth movement in the high-concentration experimental group were 1.7 times greater than in the high-concentration control group and 1.4 times greater than in the moderate-concentration experimental group (P = 0.001). On day 60, alveolar bone density increased to the original levels in all groups.
Injection of both moderate and high concentrations of PRP may accelerate orthodontic tooth movement by decreasing alveolar bone density on paradental tissues by enhancing osteoclastic activity in a transient way.
本研究旨在确定不同浓度富血小板血浆（PRP）对牙槽骨密度和正畸牙齿移动的影响。
76只大鼠分为2组：中等浓度PRP注射组（n = 38）和高浓度PRP注射组（n = 38）。每组研究5个时间点：3天、7天、14天、21天和60天。在上颌第一磨牙正畸近中移动前，将中等浓度和高浓度PRP注射到磨牙颊沟右侧，左侧作为对照。在三维数字模型上测量牙齿移动情况。通过组织形态计量学分析评估第一磨牙根内区域的牙槽骨体积密度和破骨细胞活性。
在3天、7天、14天和21天时，与对照组相比，实验组的牙槽骨密度降低（P = 0.0001）。在第3天，实验组的破骨细胞活性高于对照组（P = 0.044，P = 0.0001）。在第21天，高浓度实验组的牙齿移动量比高浓度对照组大1.7倍，比中等浓度实验组大1.4倍（P = 0.001）。在第60天，所有组的牙槽骨密度均恢复到原始水平。
注射中等浓度和高浓度PRP均可通过短暂增强破骨细胞活性降低牙周组织的牙槽骨密度，从而加速正畸牙齿移动。
