阿米卡星在血液系统恶性肿瘤中的药代动力学。
Pharmacokinetics of amikacin in hematologic malignancies.
作者信息
Kaojarern S, Maoleekoonpairoj S, Atichartakarn V
机构信息
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1406-8. doi: 10.1128/AAC.33.8.1406.
Abstract
The pharmacokinetics of amikacin in 10 patients with hematologic malignancies and 1 patient with aplastic anemia were investigated. At an administered dose of 7 mg/kg of body weight, a volume of distribution of 0.4 liters/kg, an elimination half-life of 3.0 h, and a total body clearance of 2.1 ml/min per kg, amikacin achieved a peak level in blood of 21 micrograms/ml. Results of the study revealed that there was a marked increase in volume of distribution of amikacin in these patients compared with normal.
摘要
对10例血液系统恶性肿瘤患者和1例再生障碍性贫血患者的阿米卡星药代动力学进行了研究。给予7mg/kg体重的剂量时，分布容积为0.4升/千克，消除半衰期为3.0小时，全身清除率为2.1毫升/分钟/千克，阿米卡星在血液中的峰值水平达到21微克/毫升。研究结果显示，与正常人相比，这些患者体内阿米卡星的分布容积显著增加。
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本文引用的文献
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