Rux Danielle R, Wellik Deneen M
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan.
Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, Michigan.
Dev Dyn. 2017 Apr;246(4):310-317. doi: 10.1002/dvdy.24482. Epub 2017 Jan 27.
Hox genes encode evolutionarily conserved transcription factors that control skeletal patterning in the developing embryo. They are expressed in regionally restricted domains and function to regulate the morphology of specific vertebral and long bone elements. Recent work has provided evidence that Hox genes continue to be regionally expressed in adult tissues. Fibroblasts cultured from adult tissues show broadly maintained Hox gene expression patterns. In the adult skeleton, Hox genes are expressed in progenitor-enriched populations of mesenchymal stem/stromal cells (MSCs), and genetic loss-of-function analyses have provided evidence that Hox genes function during the fracture healing process. This review will highlight our current understanding of Hox expression in the adult animal and its function in skeletal regeneration. Developmental Dynamics 246:310-317, 2017. © 2016 Wiley Periodicals, Inc.
Hox基因编码在进化上保守的转录因子，这些转录因子控制发育中胚胎的骨骼模式形成。它们在区域受限的结构域中表达，并发挥作用调节特定椎骨和长骨元件的形态。最近的研究工作提供了证据表明Hox基因在成体组织中继续进行区域表达。从成体组织培养的成纤维细胞显示出广泛维持的Hox基因表达模式。在成体骨骼中，Hox基因在间充质干/基质细胞（MSC）富含祖细胞的群体中表达，并且基因功能丧失分析提供了证据表明Hox基因在骨折愈合过程中发挥作用。本综述将重点介绍我们目前对成年动物中Hox表达及其在骨骼再生中的功能的理解。《发育动力学》246:310 - 317，2017年。©2016威利期刊公司。
