Skeletal Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States of America.
Center for Skeletal Research, Orthopedic Surgery and Medicine, UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030-4037, United States of America.
Bone. 2023 Jul;172:116760. doi: 10.1016/j.bone.2023.116760. Epub 2023 Apr 6.
Technologies on the development and differentiation of human induced pluripotent stem cells (hiPSCs) are rapidly improving, and have been applied to create cell types relevant to the bone field. Differentiation protocols to form bona fide bone-forming cells from iPSCs are available, and can be used to probe details of differentiation and function in depth. When applied to iPSCs bearing disease-causing mutations, the pathogenetic mechanisms of diseases of the skeleton can be elucidated, along with the development of novel therapeutics. These cells can also be used for development of cell therapies for cell and tissue replacement.
人类诱导多能干细胞（hiPSCs）的开发和分化技术正在迅速发展，并已应用于创建与骨骼领域相关的细胞类型。现在已有从 iPSCs 形成真正的成骨细胞的分化方案，并可用于深入探究分化和功能的细节。当应用于携带致病突变的 iPSCs 时，可以阐明骨骼疾病的发病机制，并开发新的治疗方法。这些细胞还可用于开发用于细胞和组织替代的细胞疗法。
