Swerdlow Neal R, Bhakta Savita G, Rana Brinda K, Kei Justin, Chou Hsun-Hua, Talledo Jo A
Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
Biol Psychol. 2017 Feb;123:177-186. doi: 10.1016/j.biopsycho.2016.12.011. Epub 2016 Dec 24.
Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to study normal and pathological brain function. From 2001 to 2016, we screened healthy subjects (HS) to establish their suitability for tests of drug effects on PPI. Because of the size and systematic characterization of this sample across variables of relevance to PPI, we now report these screening results.
Acoustic startle and PPI were assessed in HS to identify those eligible for studies of drug effects on PPI from 2001 to 2016, yielding 457 "eligible" subjects.
Data confirmed the consistency of PPI across this 15-year period, and supported the role of several variables previously reported to moderate either startle or PPI.
Startle and PPI are robust physiological measures that are predictably moderated by specific physiological variables in healthy adults. As such, these measures serve as robust markers of neurobiological processes in healthy and patient populations.
惊吓前脉冲抑制（PPI）作为感觉运动门控的一种操作指标，用于研究正常和病理性脑功能。从2001年到2016年，我们对健康受试者（HS）进行了筛查，以确定他们是否适合进行药物对PPI影响的测试。由于该样本在与PPI相关的变量方面的规模和系统特征，我们现在报告这些筛查结果。
对健康受试者进行听觉惊吓和PPI评估，以确定2001年至2016年期间那些有资格参与药物对PPI影响研究的受试者，共产生了457名“合格”受试者。
数据证实了这15年间PPI的一致性，并支持了先前报道的几个调节惊吓或PPI的变量的作用。
惊吓和PPI是可靠的生理指标，在健康成年人中可由特定生理变量预测性地调节。因此，这些指标可作为健康人群和患者群体神经生物学过程的可靠标志物。
