Kamceva Gordana, Arsova-Sarafinovska Zorica, Ruskovska Tatjana, Zdravkovska Milka, Kamceva-Panova Lidija, Stikova Elisaveta
Clinical Hospital, Shtip, Republic of Macedonia.
Institute of Public Health, Skopje, Republic of Macedonia.
Open Access Maced J Med Sci. 2016 Dec 15;4(4):636-640. doi: 10.3889/oamjms.2016.117. Epub 2016 Oct 28.
To determine whether cigarette smoking, as a risk factor for CAD, affects (anti)oxidant status.
The study included patients with CAD, divided according to their smoking status and the number of cigarettes smoked during a day. Biological markers of oxidative stress (concentration of oxidants and activity of antioxidant enzymes) were measured in all subjects.
The study included 300 patients with CAD, (average age of 63 ± 11 years), predominantly males. Of the total, 34.0% were active smokers, 23.0% were former smokers, and 43.0% were non-smokers. Most of the active smokers smoked 1-20 cigarettes/day. In terms of concentration of oxidants (MDA and HP) there was not a significant difference between smokers versus non-smokers. As for the activity of antioxidant enzymes (SOD, CAT and GPX), a statistically significant difference was found in the activity of GPX among the active smokers with CAD and the non-smokers with CAD (p = 0.039).
Smoking as a risk factor for CAD is closely associated with increased oxidative stress, and the number of cigarettes smoked plays an important role in increasing the level of oxidative damage and reducing antioxidant defence.
确定作为冠心病危险因素的吸烟是否会影响（抗）氧化状态。
该研究纳入了冠心病患者，根据其吸烟状况和每日吸烟量进行分组。对所有受试者测量氧化应激的生物学标志物（氧化剂浓度和抗氧化酶活性）。
该研究纳入了300例冠心病患者（平均年龄63±11岁），以男性为主。其中，34.0%为现吸烟者，23.0%为既往吸烟者，43.0%为非吸烟者。大多数现吸烟者每天吸1 - 20支烟。在氧化剂浓度（丙二醛和羟脯氨酸）方面，吸烟者与非吸烟者之间无显著差异。至于抗氧化酶（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）的活性，在患有冠心病的现吸烟者和患有冠心病的非吸烟者之间，谷胱甘肽过氧化物酶的活性存在统计学显著差异（p = 0.039）。
吸烟作为冠心病的危险因素与氧化应激增加密切相关，吸烟量在增加氧化损伤水平和降低抗氧化防御方面起着重要作用。
