Barekatain Behzad, Badiea Zohrea, Hoseini Neda
Department of Neonatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2016 Nov 28;5:176. doi: 10.4103/2277-9175.190992. eCollection 2016.
Hypocalcemia is one of the complications of phototherapy resulted from influence of phototherapy in melatonin secretion reducing corticosterone and ultimately increasing bone uptake. In this study, effect of head covering in prevention of this common and serious complication is studied.
This prospective, randomized clinical trial study conducted on premature infants with gestational age <35 weeks with jaundice. Infants were divided into two groups ( = 43). The first group (intervention group) and the second group (control group) while on the cut, underwent phototherapy using four blue fluorescent lamps in distance of 35 cm. Eyes and genitalia were protected using appropriate clothing. In the first group, head was covered using cloth helmet with a suitable size. For both groups, serum calcium was measured before and 36 h after starting phototherapy.
Mean serum calcium before phototherapy in both intervention and control groups was 8.72 ± 1.12 and 8.79 ± 0.87 mg/dL, respectively, and the difference between groups was not significant ( = 0.76). After treatment, calcium level in both intervention and control groups was 8.9 ± 0.82 and 8.43 ± 0.91, respectively, and the difference between the two groups was significant ( = 0.015). Mean serum calcium levels after phototherapy in the intervention group was -0.17 ± 1.46 (increase) and it was 0.35 ± 0.71 (decrease) in the control group. According to -test, the difference between the two groups was significant ( = 0.036).
Head covering during phototherapy probably prevents from hypocalcemia.
低钙血症是光疗的并发症之一，是由于光疗影响褪黑素分泌，降低皮质酮，最终增加骨骼摄取所致。本研究旨在探讨头部覆盖在预防这一常见且严重并发症方面的效果。
本前瞻性、随机临床试验研究针对孕周<35周的早产黄疸婴儿展开。将婴儿分为两组（每组n = 43）。第一组（干预组）和第二组（对照组）在接受光疗时，使用四盏蓝色荧光灯，灯距为35厘米。用合适的衣物保护眼睛和生殖器。在第一组中，使用尺寸合适的布头盔覆盖头部。对两组婴儿在光疗开始前及开始后36小时测量血清钙。
干预组和对照组光疗前的平均血清钙分别为8.72±1.12和8.79±0.87毫克/分升，两组间差异无统计学意义（P = 0.76）。治疗后，干预组和对照组的钙水平分别为8.9±0.82和8.43±0.91，两组间差异有统计学意义（P = 0.015）。干预组光疗后的平均血清钙水平为-0.17±1.46（升高），对照组为0.35±0.71（降低）。根据t检验结果显示，两组间差异有统计学意义（P = 0.036）。
光疗期间头部覆盖可能预防低钙血症。
