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接受光疗的黄疸新生儿中的低钙血症。

Hypocalcemia in jaundiced neonates receiving phototherapy.

作者信息

Khan Mashal, Malik Kanwal Altaf, Bai Rekha

机构信息

Dr. Mashal Khan, FCPS, MCPS, DCH, Department of Pediatrics and Neonatology, National Institute of Child Health, Karachi, Pakistan.

Dr. Kanwal Altaf Malik, MBBS, Department of Pediatrics and Neonatology, National Institute of Child Health, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2016 Nov-Dec;32(6):1449-1452. doi: 10.12669/pjms.326.10849.

DOI:10.12669/pjms.326.10849
PMID:28083043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5216299/
Abstract

OBJECTIVE

To determine the frequency of hypocalcemia in term neonates with jaundice receiving phototherapy.

METHODS

This was a cross sectional study conducted at Neonatal intensive care unit, National Institute of Child Health, Karachi from 1st January 2014 to 30th December 2014. A total of 123 term neonates with jaundice of either gender managed by phototherapy were enrolled in the study. Gestational age was assessed through modified Ballard scoring. Duration of phototherapy was recorded. A sample of 3 ml of blood was sent to the laboratory for serum calcium level before initiating phototherapy and after 24 hours of continued phototherapy. All the data were recorded in the preformed proforma. Data was analyzed using SPSS version 19. P value <0.05 was taken as significant.

RESULTS

The mean age of the neonates was 8.35±6.74 days. Mean gestational age at the time of birth was 39.08±1.37 weeks. Mean duration of jaundice was 2.4±1.20 days. Mean duration of phototherapy was 1.74±0.98 days. Serum calcium level before and after 24 hours of initiating phototherapy was 8.73±0.68 mg/dl and 7.47±0.82mg/dl respectively Frequency of hypocalcemia in term jaundiced neonates receiving phototherapy were observed in 22.76% (28/123).

CONCLUSIONS

The frequency of hypocalcemia is significant in the jaundiced neonates treated with phototherapy. One needs to be vigilant in dealing neonates in this context while serial monitoring for hypocalcemia and its complications should be considered in institutional policy and research priority.

摘要

目的

确定接受光疗的足月儿黄疸患者低钙血症的发生率。

方法

这是一项横断面研究,于2014年1月1日至2014年12月31日在卡拉奇国家儿童健康研究所新生儿重症监护病房进行。共有123例接受光疗的不同性别的足月儿黄疸患者纳入本研究。通过改良巴拉德评分评估胎龄。记录光疗持续时间。在开始光疗前和持续光疗24小时后,采集3ml血液样本送至实验室检测血清钙水平。所有数据均记录在预先设计的表格中。使用SPSS 19版软件进行数据分析。P值<0.05被视为具有统计学意义。

结果

新生儿的平均年龄为8.35±6.74天。出生时的平均胎龄为39.08±1.37周。黄疸的平均持续时间为2.4±1.20天。光疗的平均持续时间为1.74±0.98天。开始光疗前和24小时后的血清钙水平分别为8.73±0.68mg/dl和7.47±0.82mg/dl。接受光疗的足月儿黄疸患者中低钙血症的发生率为22.76%(28/123)。

结论

接受光疗的黄疸新生儿中低钙血症的发生率较高。在这种情况下处理新生儿时需要保持警惕,同时机构政策和研究重点应考虑对低钙血症及其并发症进行连续监测。

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Prevalence of phototherapy induced hypocalcemia in term neonate.足月儿光疗诱发低钙血症的患病率
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Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels.新生儿高胆红素血症和新生儿 Rh 溶血病:2010 年按区域和全球水平估计的发病率和损害程度。
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