Kong Xiangxi, Yuan Zengqiang, Cheng Jinbo
The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
School of Basic Medical Science, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
J Neurosci Res. 2017 Aug;95(8):1565-1573. doi: 10.1002/jnr.24004. Epub 2016 Dec 28.
NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and autoimmune disorders. Recent studies have indicated that the proteins of the NLR family are linked with the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), and psychological diseases. In this review, we mainly focus on the role of NLRs and the underlying signaling pathways in central nervous system (CNS) diseases. © 2016 Wiley Periodicals, Inc.
NOD样受体（NLRs）是关键的胞质模式识别受体（PRRs），在宿主先天免疫反应和免疫稳态中发挥重要作用。越来越多的证据表明，NLRs参与多种炎症性疾病，包括癌症、代谢性疾病和自身免疫性疾病。最近的研究表明，NLR家族的蛋白质与神经退行性疾病的病理生理学有关，包括阿尔茨海默病（AD）、帕金森病（PD）和多发性硬化症（MS），以及心理疾病。在本综述中，我们主要关注NLRs及其潜在信号通路在中枢神经系统（CNS）疾病中的作用。© 2016威利期刊公司。
