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乳内动脉平滑肌细胞的表型

Phenotype of smooth muscle cells in internal mammary arteries.

作者信息

Nikkari S T

机构信息

Department of Biomedical Sciences, University of Tampere, Finland.

出版信息

Artery. 1989;16(6):346-52.

PMID:2803014
Abstract

The volume fraction of synthetic organelles in smooth muscle cells (SMCs) from the intima and media of human internal mammary artery (IMA) was examined by ultrastructural morphometry. The distal ends of 8 IMAs were collected peroperatively from coronary bypass patients aged 43 to 67 years. The thickness of the intimas ranged from 3 to 49 microns. Even the thickest parts had only a few cell layers, the majority of which were SMCs. In most patients, the cytoplasmic volume fraction of synthetic organelles was significantly lower in the media than in the intima (0.11 and 0.21 respectively). The high degree of differentiation of the SMCs agrees with the absence of atherosclerosis in the IMAs.

摘要

通过超微结构形态计量学检查了来自人乳内动脉(IMA)内膜和中膜的平滑肌细胞(SMC)中合成细胞器的体积分数。手术中从43至67岁的冠状动脉搭桥患者身上采集了8条IMA的远端。内膜厚度范围为3至49微米。即使是最厚的部分也只有几层细胞,其中大多数是SMC。在大多数患者中,中膜中合成细胞器的细胞质体积分数明显低于内膜(分别为0.11和0.21)。SMC的高度分化与IMA中不存在动脉粥样硬化一致。

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