Hashimoto S
School of Medicine, Kitasato University, Sagamihara, Japan.
Artif Organs. 1989 Oct;13(5):458-63. doi: 10.1111/j.1525-1594.1989.tb01558.x.
The hydrodynamic effect of periodically fluctuating shear rate on erythrocyte destruction was quantitatively studied in vitro in comparison with constant shear rates. Uniform shear rates (less than 1,000 s-1; constant or sinusoidally fluctuating with time) were applied to heparinized canine blood contained in the concavo-convex type of Couette flow testing machine for (1.8-9.0) x 10(3) s at 24 degrees C. The results show that the erythrocyte destruction (evaluated with hemolysis ratio; plasma hemoglobin count per whole blood hemoglobin count) decreases when the exposure time of larger (greater than 500 s-1) shear rates is interspersed with smaller (less than 300 s-1) shear rates.
与恒定剪切速率相比，在体外定量研究了周期性波动的剪切速率对红细胞破坏的流体动力学效应。将均匀剪切速率（小于1000 s-1；恒定或随时间呈正弦波动）应用于24℃下凹-凸型库埃特流动试验机中含有的肝素化犬血，持续(1.8 - 9.0)×10(3) s。结果表明，当较大（大于500 s-1）剪切速率的暴露时间穿插有较小（小于300 s-1）剪切速率时，红细胞破坏（用溶血率评估；血浆血红蛋白计数与全血血红蛋白计数之比）会降低。
