Saboori Somayeh, Djalali Mahmoud, Yousefi Rad Esmaeil, Nematipour Ebrahim, Saboor-Yaraghi Ali Akbar, Javanbakht Mohammad Hassan, Eshraghian Mohammad Reza, Ramezani Atena, Koohdani Fariba
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2016 Nov;45(11):1465-1472.
Omega 3 and vitamin E are two critical nutrients which include beneficial effects in coronary artery disease (CAD). The aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin E on serum glucose and lipid levels and insulin resistance in CAD patients.
Participants of this clinical trial included 60 male patients with CAD who selected from Tehran Heart Center in Tehran, Iran in 2014. They received 4 g/day omega 3 plus 400 IU/day vitamin E (OE), 4 g/day omega 3 with vitamin E placebo (OP), or omega 3 and vitamin E placebo (PP) for two months. Serum glucose, lipids and insulin were assessed and HOMA-IR was calculated before and after the trial and effects of these nutrients on the highlighted parameters were compared within the study groups.
Serum glucose level increased significantly in OP group (=0.004), but not in OE group. OE and OP groups showed a significant decrease in fasting serum TG (=0.020 and =0.001, respectively). Serum insulin and HOMA-IR decreased significantly in OE group (=0.044 and =0.039, respectively) but did not change significantly in OP group.
Although, omega 3 supplementation may include adverse effects on serum glucose level, co-administration of omega 3 and vitamin E can beneficially decrease serum insulin and insulin resistance in CAD patients.
欧米伽3和维生素E是两种关键营养素，对冠状动脉疾病（CAD）具有有益作用。本研究的目的是评估单独补充欧米伽3或与维生素E联合补充对CAD患者血清葡萄糖、脂质水平及胰岛素抵抗的影响。
该临床试验的参与者包括2014年从伊朗德黑兰心脏中心选取的60名男性CAD患者。他们接受了为期两个月的每日4克欧米伽3加400国际单位维生素E（OE组）、每日4克欧米伽3加维生素E安慰剂（OP组）或欧米伽3和维生素E安慰剂（PP组）。在试验前后评估血清葡萄糖、脂质和胰岛素水平，并计算胰岛素抵抗指数（HOMA-IR），比较各研究组中这些营养素对上述指标的影响。
OP组血清葡萄糖水平显著升高（P=0.004），而OE组未升高。OE组和OP组空腹血清甘油三酯水平显著降低（分别为P=0.020和P=0.001）。OE组血清胰岛素和HOMA-IR显著降低（分别为P=0.044和P=0.039），而OP组无显著变化。
虽然补充欧米伽3可能对血清葡萄糖水平有不良影响，但欧米伽3与维生素E联合使用可有益地降低CAD患者的血清胰岛素水平和胰岛素抵抗。
