Department of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Otsu, Japan.
J Atheroscler Thromb. 2010 Jun 30;17(6):628-37. doi: 10.5551/jat.3657. Epub 2010 Mar 18.
Adiponectin has insulin-sensitizing, anti-atherogenic, and anti-inflammatory properties, and researchers have recently reported that omega-3 polyunsaturated fatty acid (PUFA) can increase the serum adiponectin concentration, suggesting that dietary factors, such as fish intake, may have an influence on the serum adiponectin concentration. In general, Japanese subjects consume twice as much fish as people in other countries. We hypothesized that incremental change in serum omega-3 PUFA levels by fish intake is an important regulator of serum adiponectin even in Japanese subjects. The aim of this study was to explore the relationship among fish consumption, serum omega-3 PUFA, such as eicosapentaenoic acid (EPA), levels, and serum adiponectin levels.
We recruited 17 healthy Japanese volunteers (seven men and 10 women) for an 8-week fish-diet intervention (omega-3 PUFA 3.0 g/day) without affecting total energy intake, and measured serum adiponectin concentration and fatty acid profiles.
Fish-diet intervention significantly increased the serum adiponectin concentration in women (from 13.5+/-4.6 to 15.8+/-5.2 microg/mL, p <0.01) but not in men (from 8.7+/-2.8 to 8.7+/-2.5 microg/mL). Serum omega-3 PUFA increased more in female subjects than male subjects after the fish-diet intervention (57.3+/-86.6 vs 150.9+/-46.7 microg/mL, p=0.011), suggesting that changes in omega-3 PUFA concentration may explain the different response between sexes.
A fish-based diet intervention increased the serum adiponectin concentration in young, non-obese, healthy Japanese female subjects. The increment in serum omega-3 PUFA may regulate the serum adiponectin concentration.
脂联素具有胰岛素增敏、抗动脉粥样硬化和抗炎作用，研究人员最近报道，ω-3 多不饱和脂肪酸（PUFA）可以增加血清脂联素浓度，这表明饮食因素，如鱼类摄入量，可能对血清脂联素浓度有影响。一般来说，日本人的鱼类摄入量是其他国家的两倍。我们假设，通过鱼类摄入增加血清 ω-3 PUFA 水平的增量变化是血清脂联素的重要调节剂，即使在日本受试者中也是如此。本研究旨在探讨鱼类摄入与血清 ω-3 PUFA（如二十碳五烯酸，EPA）水平和血清脂联素水平之间的关系。
我们招募了 17 名健康的日本志愿者（7 名男性和 10 名女性）进行为期 8 周的鱼类饮食干预（ω-3 PUFA 3.0 g/天），不影响总能量摄入，并测量血清脂联素浓度和脂肪酸谱。
鱼类饮食干预显著增加了女性的血清脂联素浓度（从 13.5+/-4.6 到 15.8+/-5.2 μg/mL，p<0.01），但对男性没有影响（从 8.7+/-2.8 到 8.7+/-2.5 μg/mL）。鱼类饮食干预后，女性血清 ω-3 PUFA 增加量大于男性（57.3+/-86.6 与 150.9+/-46.7 μg/mL，p=0.011），表明 ω-3 PUFA 浓度的变化可能解释了性别之间的不同反应。
基于鱼类的饮食干预增加了年轻、非肥胖、健康的日本女性血清脂联素浓度。血清 ω-3 PUFA 的增加可能调节血清脂联素浓度。
