Jiang Jiangling, Wang Jijun, Li Chunbo
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Neurosci Bull. 2017 Jun;33(3):339-347. doi: 10.1007/s12264-016-0094-x. Epub 2016 Dec 28.
In spite of the extensive application of electroconvulsive therapy (ECT), how it works remains unclear. So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.
尽管电休克疗法（ECT）已被广泛应用，但其作用机制仍不清楚。到目前为止，研究人员通过测定神经递质和细胞因子水平、使用基因和表观遗传工具以及结构和功能神经成像等方法，在弄清楚ECT治疗效果的潜在机制方面付出了巨大努力。为了帮助解决这个问题并为未来研究提供启示，本文对相关的临床试验和动物实验进行了综述。
