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耐甲氧西林金黄色葡萄球菌菌血症的治疗

Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia.

作者信息

Choo Eun Ju, Chambers Henry F

机构信息

Division of Infectious Diseases, Department of Medicine, Soonchunhyang University Hospital, Bucheon, Korea.

Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, USA.

出版信息

Infect Chemother. 2016 Dec;48(4):267-273. doi: 10.3947/ic.2016.48.4.267.

DOI:10.3947/ic.2016.48.4.267
PMID:28032484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5204005/
Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of health care-associated infections. Vancomycin remains an acceptable treatment option. There has been a welcome increase in the number of agents available for the treatment of MRSA infection. These drugs have certain differentiating attributes and may offer some advantages over vancomycin, but they also have significant limitations. These agents provide some alternative when no other options are available.

摘要

耐甲氧西林金黄色葡萄球菌（MRSA）是医疗保健相关感染的一个重要原因。万古霉素仍然是一种可接受的治疗选择。可用于治疗MRSA感染的药物数量有所增加，这是值得欢迎的。这些药物具有某些不同的特性，可能比万古霉素有一些优势，但它们也有显著的局限性。当没有其他选择时，这些药物提供了一些替代方案。

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2
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3
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4
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