Thomas Renee M, Worswick Scott, Aleshin Maria
University of California, Los Angeles, Los Angeles, California, 90095.
Dermatol Ther. 2017 Mar;30(2). doi: 10.1111/dth.12455. Epub 2016 Dec 29.
Systemic sclerosis and morphea are connective tissue diseases characterized by tightening, thickening, and hardening of the skin, leading to significant morbidity. Unfortunately, current treatment options have limited efficacy for many patients. Cutaneous manifestations of these diseases arise from excess collagen deposition and fibrosis in the skin, through pathogenic mechanisms which have yet to be extensively detailed at the causal immune and cellular levels. Research elucidating the mechanism of action of retinoic acid on collagen production in the skin and case series highlighting the success of retinoic acid on the skin manifestations of systemic sclerosis and on morphea demonstrate its promise as a treatment. Herein they will briefly review the treatment options for both systemic sclerosis and morphea, and will discuss the potential of retinoic acid as a therapy and the supporting evidence from the literature, highlighting the previously published basic science and clinical studies investigating the role of retinoic acid in the treatment of sclerotic skin diseases.
系统性硬化症和硬斑病是结缔组织疾病，其特征为皮肤紧绷、增厚和硬化，会导致严重的发病率。不幸的是，目前的治疗方案对许多患者疗效有限。这些疾病的皮肤表现源于皮肤中胶原蛋白过度沉积和纤维化，其致病机制在因果免疫和细胞水平上尚未得到广泛详细的阐述。阐明视黄酸对皮肤中胶原蛋白生成作用机制的研究以及突出视黄酸对系统性硬化症和硬斑病皮肤表现治疗成功的病例系列证明了其作为一种治疗方法的前景。在此，他们将简要回顾系统性硬化症和硬斑病的治疗方案，并讨论视黄酸作为一种治疗方法的潜力以及文献中的支持证据，重点介绍先前发表的研究视黄酸在硬化性皮肤病治疗中作用的基础科学和临床研究。
