Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
City of Äänekoski, Public Health Centre, Oral Health Care Services, Äänekoski, Finland.
J Clin Periodontol. 2017 Mar;44(3):275-282. doi: 10.1111/jcpe.12688. Epub 2017 Feb 2.
The aim of this study was to investigate whether the systemic response against a local inflammatory process in periodontium is dependent on the individual's serum lipid composition.
This study was based on a subpopulation of the Health 2000 Survey that included 878 subjects who were aged between 45 and 64 years, dentate, non-diabetic and non-rheumatic. The inflammatory condition of periodontium was measured by means of the number of teeth with deepened (4 mm or deeper) periodontal pockets. Systemic inflammation was assessed by means of the serum levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). The association between an inflammatory condition in the periodontium and the systemic inflammatory response was analysed using linear regression models.
The number of teeth with deepened periodontal pockets was associated with elevated serum IL-6 levels among subjects with an unfavourable lipid composition (low-density lipoprotein cholesterol ≥3.7 mmol/l or high-density lipoprotein cholesterol <1.3 mmol/l). There was no association between serum TNF-α levels and the number of teeth with deepened periodontal pockets in these data.
The systemic response against the inflammatory condition of periodontium varied between individuals. The variation appeared to be dependent on the serum lipid composition or related factors.
本研究旨在探讨牙周局部炎症过程引起的全身反应是否依赖于个体的血清脂质组成。
本研究基于健康 2000 调查的一个亚组，该亚组包括 878 名年龄在 45 至 64 岁之间、有牙齿、非糖尿病和非风湿性的受试者。牙周炎的炎症状况通过有深度牙周袋（4 毫米或更深）的牙齿数量来衡量。全身炎症通过血清白细胞介素 6（IL-6）和肿瘤坏死因子 alpha（TNF-α）水平来评估。使用线性回归模型分析牙周炎的炎症状况与全身炎症反应之间的关系。
在脂质组成不良（低密度脂蛋白胆固醇≥3.7mmol/L 或高密度脂蛋白胆固醇<1.3mmol/L）的受试者中，有深度牙周袋的牙齿数量与血清 IL-6 水平升高有关。在这些数据中，血清 TNF-α水平与有深度牙周袋的牙齿数量之间没有关联。
个体之间对牙周炎炎症状况的全身反应存在差异。这种差异似乎取决于血清脂质组成或相关因素。
