Haro Anniina, Saxlin Tuomas, Suominen Anna Liisa, Jula Antti, Ylöstalo Pekka
Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Oral and Maxillofacial Diseases Teaching Unit, Kuopio University Hospital, Kuopio, North Savo, Finland.
J Clin Periodontol. 2025 Oct;52(10):1454-1465. doi: 10.1111/jcpe.14202. Epub 2025 Jul 10.
To investigate whether the systemic inflammatory response against inflammatory conditions in the periodontium is related to serum apolipoprotein B (ApoB) and A1 (ApoA1) concentrations.
The study consisted of the Health 2000 Survey participants (n = 2709) aged 30-49 years. The inflammatory condition of the periodontium was assessed by means of the number of teeth with deepened (≥ 4 mm) and deep (≥ 6 mm) periodontal pockets. Systemic inflammation was measured by serum C-reactive protein (CRP) levels. The role of ApoB and ApoA1 was studied by performing regression analyses and stratified analyses (according to the median values).
In logistic regression analyses, the number of teeth with deepened (≥ 4 mm) periodontal pockets was associated with serum CRP levels among those participants whose serum ApoB concentration was ≥ 1.12 g/L. When the participants' ApoB concentration was < 1.12 g/L, such an association between deepened periodontal pockets and CRP was not observed. The direction or strength of the association between periodontal pockets and CRP was not essentially different in the ApoA1 strata.
Systemic response against poor periodontal condition varied between individuals. The variation appeared to be related more to the serum concentration of ApoB than ApoA1.
研究针对牙周炎炎症状态的全身炎症反应是否与血清载脂蛋白B（ApoB）和载脂蛋白A1（ApoA1）浓度相关。
本研究纳入了年龄在30 - 49岁的2000名健康调查参与者（n = 2709）。通过有深度加深（≥4毫米）和深度较深（≥6毫米）牙周袋的牙齿数量来评估牙周炎的炎症状态。通过血清C反应蛋白（CRP）水平来测量全身炎症。通过进行回归分析和分层分析（根据中位数）来研究ApoB和ApoA1的作用。
在逻辑回归分析中，对于血清ApoB浓度≥1.12克/升的参与者，有深度加深（≥4毫米）牙周袋的牙齿数量与血清CRP水平相关。当参与者的ApoB浓度<1.12克/升时，未观察到深度加深的牙周袋与CRP之间存在这种关联。在ApoA1分层中，牙周袋与CRP之间关联的方向或强度没有本质差异。
个体对牙周状况不佳的全身反应存在差异。这种差异似乎与血清ApoB浓度的关系比与ApoA1浓度的关系更大。
