Samarghandian Saeed, Borji Abasalt, Farkhondeh Tahere
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur. Iran.
Department of Immunogenetics, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad. Iran.
Cardiovasc Hematol Disord Drug Targets. 2017 Jul 4;17(1):11-17. doi: 10.2174/1871529X16666161229154910.
Carnosol (CS) is an ortho-diphenolic diterpene in rosemary with great antioxidant potential. This study was designed to investigate the hypolipidemic, anti-oxidant, and anti-diabetic activities of CS.
In our experiment, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, three CS (1, 5, 10 mg/kg/day)-treated diabetic groups. On the first day of the study, the diabetic groups were given streptozotocin (STZ) in a single intraperitoneal (i.p.) injection at a dose of 60 mg/kg for induction of diabetes. CS was injected (i.p.) to the treatment groups from 3 days after STZ administration during a period of 4 weeks. At the end of the experimental period, we assessed the serum levels of glucose, IL-6, TNF-α, malondialdehyde (MDA), glutathione-s transferase (GST), superoxide dismutase (SOD), catalase (CAT) activities, triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C).
The results indicated that STZ caused an elevation of serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, and it also made a reduction of serum GST, SOD, CAT, and HDL-C (p<0.001). The findings showed amelioration in the serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, GST, SOD, CAT, and HDL-C in the CS-treated diabetic groups versus the untreated group, in a dose dependent manner (p < 0.001).
In conclusion, the present investigation proposes that CS may be improved diabetes and its complications by modulation of oxidative stress and inflammatory responses.
鼠尾草酸（CS）是迷迭香中的一种邻二酚二萜，具有很强的抗氧化潜力。本研究旨在探讨CS的降血脂、抗氧化和抗糖尿病活性。
在我们的实验中，将大鼠分为以下几组，每组8只动物：对照组、未治疗的糖尿病组、三个CS（1、5、10mg/kg/天）治疗的糖尿病组。在研究的第一天，给糖尿病组腹腔注射一次链脲佐菌素（STZ），剂量为60mg/kg，以诱导糖尿病。从STZ给药后3天开始，对治疗组进行4周的CS腹腔注射。在实验期结束时，我们评估了血清葡萄糖、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）、谷胱甘肽-S转移酶（GST）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活性、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）和高密度脂蛋白（HDL-C）的水平。
结果表明，STZ导致血清葡萄糖、IL-6、TNF-α、MDA、TG、TC、LDL-C升高，同时也使血清GST、SOD、CAT和HDL-C降低（p<0.001）。研究结果显示，与未治疗组相比，CS治疗的糖尿病组血清葡萄糖、IL-6、TNF-α、MDA、TG、TC、LDL-C、GST、SOD、CAT和HDL-C有改善，且呈剂量依赖性（p<0.001）。
总之，本研究表明CS可能通过调节氧化应激和炎症反应改善糖尿病及其并发症。
