Hoesli R C, Ludwig M L, Michmerhuizen N L, Rosko A J, Spector M E, Brenner J C, Birkeland A C
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Eur J Surg Oncol. 2017 May;43(5):884-892. doi: 10.1016/j.ejso.2016.12.002. Epub 2016 Dec 15.
Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.
头颈部鳞状细胞癌（HNSCC）仍然是一种常见且致命的疾病。从历史上看，外科手术和放化疗治疗取得的成效有限，对头颈部鳞状细胞癌基因驱动因素的了解也很有限。随着近期针对头颈部鳞状细胞癌的新一代测序研究，我们开始了解头颈部鳞状细胞癌的基因图谱，并开始为患者识别和推进靶向治疗方案。在本综述中，我们描述了头颈部鳞状细胞癌测序研究的当前知识和最新进展，讨论了当前基因组分析的局限性和未来方向，并强调了为治疗这一重要疾病正在进行的转化医学进展。
