来自中国的产多重耐药β-内酰胺酶OXA-357的皮氏不动杆菌ST865临床分离株的基因组序列草图
Draft genome sequence of a multidrug-resistant beta-lactamase OXA-357-producing Acinetobacter pittii ST865 clinical isolate from China.
作者信息
Wang Jianfeng, Chen Yan, Wu Liyan, Chen Yu, Xu Liqun
机构信息
The Affiliated Hospital of Hangzhou Normal University, Department of Respiratory Diseases, Hangzhou, Zhejiang, China.
The First Affiliated Hospital of Zhejiang Chinese Medical University, Department of General Practice, Hangzhou, Zhejiang, China.
出版信息
Braz J Microbiol. 2017 Apr-Jun;48(2):196-197. doi: 10.1016/j.bjm.2016.10.020. Epub 2016 Dec 14.
Abstract
Worldwide increasing emergence of carbapenem-resistant Acinetobacter spp. has rendered the limited availability of effective antimicrobial agents and has become a major public health concern. In this study, we report the draft genome sequence of A. pittii TCM156, a multidrug-resistant isolate that harbored the bla gene. The genome sequence was further analyzed by various bioinformatics methods. The genome size was estimated to be 3,807,313bp with 3508 predicted coding regions and G+C content is 38.7%. These findings have raised awareness of the possible emergence of OXA-type enzyme-producing A. pittii isolate in China.
摘要
全球范围内，耐碳青霉烯类不动杆菌属细菌的出现日益增多，导致有效抗菌药物的供应有限，并已成为一个主要的公共卫生问题。在本研究中，我们报告了一株携带bla基因的多重耐药菌株皮氏不动杆菌TCM156的基因组序列草图。通过各种生物信息学方法对该基因组序列进行了进一步分析。基因组大小估计为3,807,313bp，预测编码区有3508个，G+C含量为38.7%。这些发现提高了人们对中国可能出现产OXA型酶的皮氏不动杆菌分离株的认识。
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