Ji Peng, Yang Kexin, Xu Qingqing, Qin Guilin, Zhu Qianyu, Qian Ying, Yao Wenshui
College of Pharmacy and Chemistry & Chemical Engineering, Jiangsu Provincial Key Laboratory of Chiral Pharmaceutical Chemicals Biologically Manufacturing, Taizhou University, Taizhou 225300, China.
Department of Anesthesiology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China.
Pharmaceuticals (Basel). 2023 Oct 2;16(10):1394. doi: 10.3390/ph16101394.
Cancer is still one of the major factors threatening public health, with morbidity and mortality rates at the forefront of the world. Clinical drawbacks, such as high toxicity and side effects of drug therapy, and easy recurrence after surgery affect its therapeutic effect. Gas signaling molecules are essential in maintaining biological homeostasis and physiological functions as specific chemical substances for biological information transfer. In recent years, the physiological regulatory functions of gas molecules in the cancer process have been gradually revealed and have shown broad application prospects in tumor therapy. In this paper, standard gas therapies are classified and introduced. Taking H, CO, NO, CO, HS, and SO gases as examples, the research progress and application of gas therapies in malignant tumors are mainly introduced in terms of biological characteristics, anticancer mechanisms, and treatment strategies. Finally, the problems and prospects for developing gases as anticancer drugs are outlined.
癌症仍然是威胁公众健康的主要因素之一，其发病率和死亡率位居世界前列。临床存在一些弊端，如药物治疗的高毒性和副作用，以及手术后易复发等，影响了其治疗效果。气体信号分子作为生物信息传递的特定化学物质，在维持生物体内稳态和生理功能方面至关重要。近年来，气体分子在癌症过程中的生理调节功能逐渐被揭示，并在肿瘤治疗中显示出广阔的应用前景。本文对标准气体疗法进行了分类介绍。以氢气、一氧化碳、一氧化氮、二氧化碳、硫化氢和二氧化硫气体为例，主要从生物学特性、抗癌机制和治疗策略等方面介绍了气体疗法在恶性肿瘤中的研究进展及应用。最后，概述了开发气体作为抗癌药物存在的问题和前景。
