Hoddy Kristin K, Bhutani Surabhi, Phillips Shane A, Varady Krista A
Department of Kinesiology and Nutrition, University of Illinois at Chicago , Chicago, IL, USA.
Department of Physical Therapy, University of Illinois at Chicago , Chicago, IL, USA.
Nutr Healthy Aging. 2016 Oct 27;4(1):63-71. doi: 10.3233/NHA-1611.
Obesity can have deleterious effects on insulin sensitivity leading to endothelial dysfunction. Whether alternate day fasting (ADF) can ameliorate insulin sensitivity in a way that improves endothelial function remains unknown. This study examined the impact of ADF on endothelium dependent flow mediated dilation (FMD) in obese subjects with different degrees of insulin resistance. Obese non-diabetic adults ( = 54) participated in an 8-week ADF protocol (25% energy intake "fast day", alternated with ad libitum intake "feast day"). Subjects were divided into tertiles according to degree of insulin resistance based on HOMA-IR (Homeostatic model assessment-Insulin resistance): tertile 1 (0.8-2.4), tertile 2 (2.5-3.6), tertile 3 (3.7-12.4). Body weight decreased ( < 0.001) by 4% in each tertile. Fat mass, lean mass, and visceral fat mass also decreased ( < 0.001) similarly in each tertile. After 8 weeks of ADF, FMD and adiponectin differed ( < 0.05) between tertile 1 (3±0%; 26±23%) versus tertile 3 (-3±0%; -13±10%). Changes in leptin did not differ between tertiles (tertile 1: -23±7%; tertile 2: -20±7%; tertile 3: -9±7%). Fasting glucose did not change in any tertile. Fasting insulin and HOMA-IR differed ( < 0.05) between tertile 1 (10±11%; 11±11%) versus tertile 3 (-27±8%; -30±9%). Plasma lipids, blood pressure and heart rate did not change in any tertile. Our data suggest that ADF may be effective for decreasing insulin resistance in insulin resistant subjects, but these changes have no effect on endothelial function.
肥胖会对胰岛素敏感性产生有害影响，导致内皮功能障碍。隔日禁食（ADF）是否能以改善内皮功能的方式改善胰岛素敏感性尚不清楚。本研究调查了ADF对不同程度胰岛素抵抗的肥胖受试者内皮依赖性血流介导的血管舒张（FMD）的影响。肥胖非糖尿病成年人（n = 54）参与了一项为期8周的ADF方案（能量摄入的25%为“禁食日”，与随意摄入的“盛宴日”交替）。根据基于HOMA-IR（稳态模型评估-胰岛素抵抗）的胰岛素抵抗程度，将受试者分为三分位数：三分位数1（0.8 - 2.4）、三分位数2（2.5 - 3.6）、三分位数3（3.7 - 12.4）。每个三分位数的体重均下降（P < 0.001）4%。每个三分位数的脂肪量、瘦体重和内脏脂肪量也同样下降（P < 0.001）。ADF 8周后，三分位数1（3±0%；26±23%）与三分位数3（-3±0%；-13±10%）之间的FMD和脂联素存在差异（P < 0.05）。瘦素的变化在三分位数之间无差异（三分位数1：-23±7%；三分位数2：-20±7%；三分位数3：-9±7%）。任何三分位数的空腹血糖均未改变。三分位数1（10±11%；11±11%）与三分位数3（-27±8%；-30±9%）之间的空腹胰岛素和HOMA-IR存在差异（P < 0.05）。任何三分位数的血脂、血压和心率均未改变。我们的数据表明，ADF可能对降低胰岛素抵抗的受试者的胰岛素抵抗有效，但这些变化对内皮功能无影响。
