Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Nutr Diabetes. 2013 May 27;3(5):e71. doi: 10.1038/nutd.2013.14.
Alternate day fasting (ADF) with a low-fat (LF) diet improves brachial artery flow-mediated dilation (FMD). Whether these beneficial effects can be reproduced with a high-fat (HF) diet remains unclear.
This study compared the effects of ADF-HF to ADF-LF regimens on FMD. The role that adipokines have in mediating this effect was also investigated.
Thirty-two obese subjects were randomized to an ADF-HF (45% fat) or ADF-LF diet (25% fat), consisting of two phases: (1) a 2-week baseline weight maintenance period and (2) an 8-week ADF weight loss period. Food was provided throughout the study.
Body weight was reduced (P<0.0001) in the ADF-HF (4.4±1.0 kg) and ADF-LF group (3.7±0.7 kg). FMD decreased (P<0.05) by ADF-HF relative to baseline (7±1 to 5±2%) and increased (P<0.05) by ADF-LF (5±1 to 7±2%). Blood pressure remained unchanged in both groups. Adiponectin increased (P<0.05) in the ADF-HF (43±7%) and ADF-LF group (51±7%). Leptin and resistin decreased (P<0.05) in the ADF-HF (32±5%; 23±5%) and ADF-LF group (30±3%; 27±4%). Increases in adiponectin were associated with augmented FMD in the ADF-LF group only (r=0.34, P=0.03).
Thus, improvements in FMD with ADF may only occur with LF diets and not with HF diets, and adipokines may not have a significant role in mediating this effect.
隔日禁食（ADF）结合低脂肪（LF）饮食可改善肱动脉血流介导的扩张（FMD）。目前尚不清楚这些有益效果是否可以通过高脂肪（HF）饮食再现。
本研究比较了 ADF-HF 与 ADF-LF 方案对 FMD 的影响。还研究了 adipokines 在介导这种作用中的作用。
32 名肥胖受试者被随机分为 ADF-HF（45%脂肪）或 ADF-LF 饮食（25%脂肪）组，包括两个阶段：（1）为期 2 周的基线体重维持期和（2）为期 8 周的 ADF 减肥期。在整个研究过程中提供食物。
ADF-HF（4.4±1.0 kg）和 ADF-LF 组（3.7±0.7 kg）体重减轻（P<0.0001）。与基线相比，ADF-HF 使 FMD 降低（P<0.05）（7±1 至 5±2%），而 ADF-LF 使 FMD 升高（P<0.05）（5±1 至 7±2%）。两组血压均无变化。ADF-HF（43±7%）和 ADF-LF 组（51±7%）的 adiponectin 增加（P<0.05）。ADF-HF（32±5%；23±5%）和 ADF-LF 组（30±3%；27±4%）的瘦素和抵抗素降低（P<0.05）。ADF-LF 组 adiponectin 的增加与 FMD 的增加呈正相关（r=0.34，P=0.03）。
因此，ADF 引起的 FMD 改善可能仅发生在 LF 饮食中，而不是在 HF 饮食中，并且 adipokines 可能在介导这种作用中没有重要作用。
