Welton Stephanie, Minty Robert, O'Driscoll Teresa, Willms Hannah, Poirier Denise, Madden Sharen, Kelly Len
Researcher for the Anishinaabe Bimaadiziwin Research Program in Sioux Lookout, Ont.
Family physician practising at the Sioux Lookout Meno Ya Win Health Centre and Assistant Professor in the Division of Clinical Sciences at the Northern Ontario School of Medicine.
Can Fam Physician. 2020 Feb;66(2):117-125.
To examine the evidence for intermittent fasting (IF), an alternative to calorie-restricted diets, in treating obesity, an important health concern in Canada with few effective office-based treatment strategies.
A MEDLINE and EMBASE search from January 1, 2000, to July 1, 2019, yielded 1200 results using the key words and .
Forty-one articles describing 27 trials addressed weight loss in overweight and obese patients: 18 small randomized controlled trials (level I evidence) and 9 trials comparing weight after IF to baseline weight with no control group (level II evidence). Studies were often of short duration (2 to 26 weeks) with low enrolment (10 to 244 participants); 2 were of 1-year duration. Protocols varied, with only 5 studies including patients with type 2 diabetes.
All 27 IF trials found weight loss of 0.8% to 13.0% of baseline weight with no serious adverse events. Twelve studies comparing IF to calorie restriction found equivalent results. The 5 studies that included patients with type 2 diabetes documented improved glycemic control.
Intermittent fasting shows promise for the treatment of obesity. To date, the studies have been small and of short duration. Longer-term research is needed to understand the sustainable role IF can play in weight loss.
研究间歇性禁食（IF）作为热量限制饮食的替代方法，用于治疗肥胖症的证据。肥胖症是加拿大一个重要的健康问题，而有效的门诊治疗策略较少。
对2000年1月1日至2019年7月1日期间的MEDLINE和EMBASE进行检索，使用关键词检索得到1200条结果。
41篇描述27项试验的文章探讨了超重和肥胖患者的体重减轻情况：18项小型随机对照试验（I级证据）和9项将IF后的体重与基线体重进行比较且无对照组的试验（II级证据）。研究持续时间通常较短（2至26周），入组人数较少（10至244名参与者）；2项研究持续时间为1年。研究方案各不相同，只有5项研究纳入了2型糖尿病患者。
所有27项IF试验均发现体重减轻了基线体重的0.8%至13.0%，且无严重不良事件。12项将IF与热量限制进行比较的研究得到了相同的结果。纳入2型糖尿病患者的5项研究记录了血糖控制的改善。
间歇性禁食在治疗肥胖症方面显示出前景。迄今为止，研究规模较小且持续时间较短。需要进行长期研究以了解IF在减肥中可持续发挥的作用。
