Kelley A E, Gauthier A M, Lang C G
Department of Psychology, Harvard University, Cambridge, MA 02138.
Behav Brain Res. 1989 Oct 1;35(1):27-39. doi: 10.1016/s0166-4328(89)80005-1.
The mammalian striatum, although cytoarchitecturally consistent throughout its extent, is considered heterogeneous with regard to functional subregions. The present study investigated the behavioral effects of amphetamine microinjections into specific subregions within the striatum. These three sites, the nucleus accumbens (N.Acc), ventrolateral striatum (VLS) and dorsolateral striatum (DLS), were selected on the basis of their differential afferent projections. Three groups of rats were implanted with guide cannulae aimed at these sites, and were tested in their home cages following intrastriatal administration of saline, 0.1, 1.0, or 5.0 micrograms amphetamine (0.5 microliters bilaterally). Spontaneous motor and ingestive behaviors (the rats were maintained ad libitum) were observed and recorded over a 40-min session. Amphetamine injected into the N.Acc produced a dose-dependent increase in locomotion and rearing and decreased the average duration of rears. No effects were found on feeding or drinking. Amphetamine injected into the VLS had no overall effects on motor behavior, except to decrease locomotion and rearing in the first 10 min following the high dose. During this period, however, VLS amphetamine-treated animals showed increased levels of feeding, with no effects on drinking. At the higher doses of amphetamine infused into the VLS, some rats showed a marked but short-lasting stereotyped biting of the forepaws. Amphetamine injected into the DLS resulted in no measurable changes in behavior. Findings are interpreted as evidence for the diversity of the striatal dopamine system, based on its limbic and cortical connections, and suggest in particular that the ventrolateral striatum may critically mediate oral behavior.
哺乳动物的纹状体，尽管在其整个范围内细胞结构一致，但在功能亚区方面被认为是异质性的。本研究调查了向纹状体内特定亚区微量注射苯丙胺的行为效应。根据其不同的传入投射，选择了三个部位，即伏隔核（N.Acc）、腹外侧纹状体（VLS）和背外侧纹状体（DLS）。三组大鼠植入了针对这些部位的引导套管，并在纹状体内注射生理盐水、0.1、1.0或5.0微克苯丙胺（双侧各0.5微升）后在其饲养笼中进行测试。在40分钟的时间段内观察并记录自发运动和摄食行为（大鼠自由进食）。向伏隔核注射苯丙胺会使运动和竖毛行为呈剂量依赖性增加，并缩短平均竖毛持续时间。对进食或饮水没有影响。向腹外侧纹状体注射苯丙胺对运动行为没有总体影响，只是在高剂量注射后的前10分钟内会减少运动和竖毛行为。然而，在此期间，接受腹外侧纹状体苯丙胺治疗的动物进食水平增加，对饮水没有影响。在向腹外侧纹状体注入较高剂量的苯丙胺时，一些大鼠表现出明显但持续时间较短的前爪刻板啃咬行为。向背外侧纹状体注射苯丙胺导致行为没有可测量的变化。研究结果被解释为基于其边缘和皮质连接的纹状体多巴胺系统多样性的证据，尤其表明腹外侧纹状体可能对口腔行为起关键调节作用。
