用于实验性神经肿瘤学的神经胶质瘤动物模型的开发。
The development of an animal model of glioma for use in experimental neuro-oncology.
作者信息
Bradford R, Darling J L, Thomas D G
机构信息
Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, United Kingdom.
出版信息
Br J Neurosurg. 1989;3(2):197-210. doi: 10.3109/02688698909002795.
A cell line, 497-P(1), derived from the VM spontaneous murine astrocytoma has been used to develop an in vitro in vivo model of human glioma. This paper describes the growth characteristics of tumours produced after intracerebral or subcutaneous inoculation of 497-P(1) cells into syngeneic VM mice. The results show that cell line 497-P(1) provides the basis for a reproducible animal model of glioma which fulfils many of the criteria required for experimental therapy studies.
一种源自VM自发性小鼠星形细胞瘤的细胞系497-P(1)已被用于建立人胶质瘤的体外-体内模型。本文描述了将497-P(1)细胞接种到同基因VM小鼠脑内或皮下后所产生肿瘤的生长特性。结果表明，细胞系497-P(1)为可重复的胶质瘤动物模型提供了基础，该模型满足实验治疗研究所需的许多标准。
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