希腊分离的家畜相关耐甲氧西林金黄色葡萄球菌的遗传特征。
Genetic characterization of livestock-associated methicillin-resistant Staphylococcus aureus isolated in Greece.
机构信息
Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 541 24, Thessaloniki, Greece.
Laboratory of Food Hygiene-Veterinary Public Health, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
Braz J Microbiol. 2021 Dec;52(4):2091-2096. doi: 10.1007/s42770-021-00587-z. Epub 2021 Aug 13.
The interest in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) strains is increasing due to their wide distribution and transmission even in persons without previous contact with livestock, and these strains pose a public health threat. The aim of the study was the genetic characterization of the whole genome of two epidemiologically unrelated t034 LA-MRSA strains previously isolated from the nasal cavities of a goat and a farmer in Greece. Both strains were assigned to the ST398-Vc-t034 type and they were carrying a single transposon identical to Tn6133. They harbored genes conferring resistance to several antibiotics (aminoglycosides, β-lactams, macrolides, streptogramin B, tetracycline, and trimethoprim), and genes associated with virulence (enterotoxins, γ-hemolysins, and aureolysin). The present study can serve as baseline for further LA-MRSA epidemiological and evolutionary studies in Greece, while awareness and increased surveillance are needed to avoid their spread.
由于与牲畜相关的耐甲氧西林金黄色葡萄球菌（LA-MRSA）菌株分布广泛且传播迅速，即使在没有与牲畜接触史的人群中也会传播，因此人们对这些菌株的兴趣日益增加，这些菌株对公共健康构成了威胁。本研究的目的是对先前从希腊的一只山羊和一位农民鼻腔中分离出的两株具有遗传相关性的、无关联的 t034 型 LA-MRSA 菌株的全基因组进行基因特征分析。这两种菌株均被归为 ST398-Vc-t034 型，且均携带与 Tn6133 相同的单个转座子。它们携带有可赋予对抗生素（氨基糖苷类、β-内酰胺类、大环内酯类、糖肽类、四环素类和甲氧苄啶类）耐药性的基因，以及与毒力相关的基因（肠毒素、γ-溶血性素和金葡菌溶素）。本研究可作为希腊进一步开展 LA-MRSA 流行病学和进化研究的基线，同时需要提高认识和加强监测，以避免其传播。
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