Dodds R A, Emery R J, Klenerman L, Chayen J, Bitensky L
Division of Cellular Biology, Kennedy Institute of Rheumatology, Hammersmith, London, U.K.
Bone. 1989;10(4):251-4. doi: 10.1016/8756-3282(89)90061-6.
On the basis of studies with bone-seeking isotopes, it is generally believed that the metabolic activity of osteoblasts of the trabecular bone is greater than that of the osteoblasts of the cortex. This implies that the oxidative activity, which provides the energy for biosyntheses, will also be greater in the former than in the latter. In the present study, direct measurement of the activities of representative enzymes of the major oxidative pathways, as well as of alkaline phosphatase, showed that the reverse pertained. However, owing to the greater cellularity of trabecular bone, the activity per unit mass of bone may be higher in the trabecular bone.
基于对亲骨同位素的研究，人们普遍认为小梁骨成骨细胞的代谢活性高于皮质骨成骨细胞。这意味着为生物合成提供能量的氧化活性在前一种细胞中也会高于后一种细胞。在本研究中，对主要氧化途径的代表性酶以及碱性磷酸酶的活性进行直接测量，结果显示情况相反。然而，由于小梁骨的细胞密度更大，单位骨质量的活性在小梁骨中可能更高。
