Agner T, Serup J
Department of Dermatology, Rigshospitalet, Copenhagen, Denmark.
Br J Dermatol. 1989 Sep;121(3):323-8. doi: 10.1111/j.1365-2133.1989.tb01425.x.
In order to investigate a possible seasonal variation in the skin response to irritants, 17 healthy volunteers were patch tested with sodium lauryl sulphate (SLS) and nonanoic acid in the winter and summer. The response to these irritants was quantified by visual scoring, measurement of transepidermal water loss, measurement of electrical conductance indicating the hydration state of the superficial epidermis, measurement of blood flow by laser Doppler and measurement of oedema by ultrasound A-scan. Significantly stronger reactions to SLS were found during the winter than the summer as indicated by visual scoring and by measurements of transepidermal water loss, whereas no significant seasonal variation was found in the response to nonanoic acid. A decreased hydration state of the epidermis of unexposed skin was found during the winter, and we believe this to be responsible for the increased susceptibility to SLS during this season.
为了研究皮肤对刺激物的反应是否存在季节性变化，17名健康志愿者在冬季和夏季接受了月桂醇硫酸酯钠（SLS）和壬酸的斑贴试验。通过视觉评分、经表皮水分流失测量、指示表皮浅层水合状态的电导测量、激光多普勒血流测量以及超声A扫描水肿测量对这些刺激物的反应进行量化。视觉评分和经表皮水分流失测量结果表明，冬季对SLS的反应明显强于夏季，而对壬酸的反应未发现明显的季节性变化。冬季发现未暴露皮肤的表皮水合状态降低，我们认为这是该季节对SLS易感性增加的原因。
