Lammintausta K, Maibach H I, Wilson D
Department of Dermatology, University of California, San Francisco 94143.
Contact Dermatitis. 1987 Nov;17(5):276-80. doi: 10.1111/j.1600-0536.1987.tb01477.x.
Repeated, daily, open sodium lauryl sulfate (SLS) applications caused slight alterations in transepidermal water loss (TEWL) and dielectric water content (DEWC) in males and females. No erythema developed. Inter-individual variation in skin reactivity was demonstrated; sex-related patterns in reactivity to open cumulative irritant exposure did not exist. In patch testing with 0.5 and 1% SLS, reflecting acute irritation capacity, the reaction pattern, assessed by TEWL, DEWC, laser Doppler velocimetry (LDV) and visual scoring (VS), differed from that induced by open, cumulative SLS irritation. Again, inter-individual variation in the reactivity was demonstrated; significant sex-related differences did not develop. Individual reactivity showed considerable variation in acute and cumulative irritant response and was greater than the sex-related variation. We did not identify responses demonstrating that women have delicate (easily irritated) skin, nor that males have "tougher" skin than females.
每日重复开放性涂抹月桂醇硫酸酯钠（SLS），会使男性和女性的经表皮水分流失（TEWL）和介电水含量（DEWC）出现轻微变化。未出现红斑。研究表明皮肤反应存在个体间差异；对于开放性累积刺激性暴露，不存在与性别相关的反应模式。在使用0.5%和1% SLS进行斑贴试验以反映急性刺激能力时，通过TEWL、DEWC、激光多普勒血流仪（LDV）和视觉评分（VS）评估的反应模式，与开放性累积SLS刺激所诱导的反应模式不同。同样，也证明了反应存在个体间差异；未出现显著的性别相关差异。个体反应在急性和累积刺激性反应方面表现出相当大的差异，且大于与性别相关的差异。我们未发现能表明女性皮肤娇嫩（易受刺激）或男性皮肤比女性“更坚韧”的反应。
